Seminars in Diagnostic Pathology
Volume 27, Issue 1 , Pages 5-12 , February 2010

Epitheliosis, infiltrating epitheliosis, and radial scar

  • Vincenzo Eusebi, MD, FRCPath

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Vincenzo Eusebi, MD, FRCPath, Sezione Anatomia Patologica, Ospedale Bellaria, Via Altura 3, 40139 Bologna, Italy
  • ,
  • Rosemary R. Millis, MB, BS, FRCPath, DSc(Med)

References 

  1. Azzopardi JG, Ahmed A, Millis RR. Problems in Breast Pathology. London, United Kingdom: WB Saunders Company; 1979;
  2. Clement PB, Young RH, Azzopardi JG. Collagenous spherulosis of the breast. Am J Surg Pathol. 1987;11:411–417
  3. Damiani S, Dina R, Eusebi V. Cytologic grading of aggressive and nonaggressive variants of papillary thyroid carcinoma. Am J Clin Pathol. 1994;101:651–655
  4. Eusebi V, Damiani S, Ellis IO, et al. Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: Report of 5 cases. Am J Surg Pathol. 2003;27:1114–1118
  5. Tavassoli FA, Majeste RM, Snyder RC. Intranuclear helioid inclusions in mammary intraductal hyperplasias. Ultrastruct Pathol. 1991;15:267–279
  6. Rosen PP. Rosen's Breast Pathology. ed 3. Philadelphia, PA: Lippincott Williams & Wilkins; 2009;
  7. Hamperl H. Strahlige Narben und obliterierende Mastopathie. Virchows Arch A (Pathol Anat). 1975;369:55–68
  8. Eusebi V, Grassigli A, Grosso F. Lesioni focali sclero-elastotiche mammarie simulanti il carcinoma infiltrante. Pathologica. 1976;68:507–518
  9. Davies JD. Hyperelastosis, obliteration and fibrous plaques in major ducts of the human breast. J Pathol. 1973;110:13–26
  10. Tavassoli FA, Eusebi V. Tumors of the Breast. ed 4. Washington, DC: American Registry of Pathology/AFIP; 2009;
  11. Flotte TJ, Bell DA, Greco MA. Tubular carcinoma and sclerosing adenosis: The use of basal lamina as a differential feature. Am J Surg Pathol. 1980;4:75–77
  12. Ekblom P, Miettinen M, Forsman L, et al. Basement membrane and apocrine epithelial antigens in differential diagnosis between tubular carcinoma and sclerosing adenosis of the breast. J Clin Pathol. 1984;37:357–363
  13. Eusebi V, Foschini MP, Betts CM, et al. Microglandular adenosis, apocrine adenosis, and tubular carcinoma of the breast. Am J Surg Pathol. 1993;17:99–109
  14. Eusebi V, Betts CM, Bussolati G. Tubular carcinoma: A variant of secretory breast carcinoma. Histopathology. 1979;3:407–419
  15. Tavassoli FA. Pathology of the Breast. ed 2. Stamford, CT: Appleton-Lange; 1999;
  16. Deos PH, Norris HJ. Well-differentiated (tubular) carcinoma of the breast (A clinicopathologic study of 145 pure and mixed cases). Am J Clin Pathol. 1982;78:1–7
  17. Sloane JP, Mayers MM. Carcinoma and atypical hyperplasia in radial scars and complex sclerosing lesions: Importance of lesion size and patient age. Histopathology. 1993;23:225–231
  18. McDivitt RW, Stewart FW, Berg JW. Tumors of the breast, in Atlas of Tumor Pathology, Second Series, fascicle 2. Washington, DC: Armed Forces Institute of Pathology; 1968;
  19. Fenoglio CM, Lattes R. Sclerosing papillary proliferations in the female breast (A benign lesion often mistaken for carcinoma). Cancer. 1974;33:691–700
  20. Page DL, Anderson TJ. Diagnostic Histopathology of the Breast. Edinburgh, United Kingdom: Churchill Livingstone; 1987;
  21. Fisher ER, Palekar AS, Kotwal N, et al. A nonencapsulated sclerosing lesion of the breast. Am J Clin Pathol. 1979;71:240–246
  22. Rickert RR, Kalisher L, Hutter RV. Indurative mastopathy: A benign sclerosing lesion of the breast with elastosis which may simulate carcinoma. Cancer. 1981;47:561–571
  23. Wellings SR, Alpers CE. Subgross pathologic features and incidence of radial scars in the breast. Hum Pathol. 1984;15:475–479
  24. Manfrin E, Remo A, Falsirollo F, et al. Risk of neoplastic transformation in asymptomatic radial scar (Analysis of 117 cases). Breast Cancer Res Treat. 2008;107:371–377
  25. Sanders ME, Page DL, Simpson JF, et al. Interdependence of radial scar and proliferative disease with respect to invasive breast carcinoma risk in patients with benign breast biopsies. Cancer. 2006;106:1453–1461
  26. Denley H, Pinder SE, Tan PH, et al. Metaplastic carcinoma of the breast arising within complex sclerosing lesion: A report of five cases. Histopathology. 2000;36:203–209
  27. Tremblay G, Buell RH, Seemayer TA. Elastosis in benign sclerosing ductal proliferation of the female breast. Am J Surg Pathol. 1977;1:155–159
  28. Andersen JA, Gram JB. Radial scar in the female breast (A long term follow up study of 32 cases). Cancer. 1984;53:2557–2560
  29. Linell F. Radial scars of the breast and their significance for diagnosis and prognosis. Verh Dtsch Ges Pathol. 1985;69:108–118
  30. Nielsen M, Jensen J, Andersen JA. An autopsy study of radial scar in the female breast. Histopathology. 1985;9:287–295
  31. Nielsen M, Christensen L, Andersen J. Radial scars in women with breast cancer. Cancer. 1987;59:1019–1025
  32. Jacobs TW, Schnitt SJ, Raza S, et al. Radial scars in breast biopsies: Pathologic features and clinical importance. Pathol Case Rev 194. 1999;
  33. Jacobs TW, Byrne C, Colditz G, et al. Radial scars in benign breast-biopsy specimens and the risk of breast cancer. N Engl J Med. 1999;340:430–436

PII: S0740-2570(09)00098-7

doi: 10.1053/j.semdp.2009.12.008

Seminars in Diagnostic Pathology
Volume 27, Issue 1 , Pages 5-12 , February 2010