Seminars in Diagnostic Pathology
Volume 27, Issue 1 , Pages 77-90 , February 2010

Salivary gland-type tumors of the breast: a spectrum of benign and malignant tumors including “triple negative carcinomas” of low malignant potential

  • Maria P. Foschini, MD

      Affiliations

    • Department of Hematology and Oncology, Section of Anatomic Pathology at Bellaria Hospital, “L. and A. Seragnoli” University of Bologna, Bologna, Italy
    • Corresponding Author InformationAddress reprint requests and correspondence: Maria P. Foschini, MD, Anatomia Patologica, Università di Bologna, Ospedale Bellaria, Via Altura 3, 40139 Bologna, Italy
    • ,
  • Thomas Krausz, MD, FRCPath

      Affiliations

    • Department of Pathology, University of Chicago, Chicago, Illinois

References 

  1. Azzopardi JG. Problems in breast pathology. In:  Azzopardi JG,  Bennington JL editor. Major Problems in Pathology. London, United Kingdom: WB Saunders; 1979;
  2. Foschini MP, Reis-Filho J, Eusebi V, et al. Salivary gland-like tumours of the breast: Surgical and molecular pathology. J Clin Pathol. 2003;56:497–506
  3. Bennett AK, Mills SE, Wick MR. Salivary-type neoplasms of the breast and lung. Semin Diagn Pathol. 2003;20:279–304
  4. Hamperl H. The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors. Curr Top Pathol. 1970;53:161–220
  5. Foschini MP, Eusebi V. Carcinomas of the breast showing myoepithelial cell differentiation (A review of the literature). Virchows Arch. 1998;432:303–310
  6. Narita T, Matsuda K. Pleomorphic adenoma of the breast: Case report and review of the literature. Pathol Int. 1995;45:441–447
  7. Simha MR, Doctor VM, Udawadia TE. Mixed tumor of salivary gland type of the male breast. Indian J Cancer. 1992;28:14–17
  8. Makek M, von Hochstetter AR. Pleomorphic adenoma of the human breast. J Surg Oncol. 1980;14:281–286
  9. Agnantis NJ, Maounis N, Priovolou-Papaevangelou M, et al. Pleomorphic adenoma of the human female breast. Pathol Res Pract. 1992;188:235–240
  10. Mizukami Y, Takayama T, Takemura A. Pleomorphic adenoma of the breast. Radiat Med. 2008;26:442–445
  11. Parham DM, Evans A. Pleomorphic adenoma of the breast, a potential for the misdiagnosis of malignancy on fine needle aspiration (FNA). Cytopathology. 1998;9:343–348
  12. Iyengar P, Cody HS, Brogi E. Pleomorphic adenoma of the breast: Case report and review of the literature. Diagn Cytopathol. 2005;33:416–420
  13. Lomax-Smith JD, Azzopardi JG. The hyaline cell: A distinctive feature of “mixed” salivary tumours. Histopathology. 1978;2:77–92
  14. Geurts JM, Schoenmakers EF, Röijer E, et al. Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. Oncogene. 1998;16:865–878
  15. Åström AK, Voz AL, Kas K, et al. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: Identification of SII as a new fusion partner gene. Cancer Res. 1999;59:918–923
  16. Voz ML, Agten NS, Van de Ven WJ, et al. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Cancer Res. 2000;60:106–113
  17. Van Dyck F, Declercq J, Braem CV, et al. PLAG1, the prototype of the PLAG gene family: Versatility in tumour development [review]. Int J Oncol. 2007;30:765–774
  18. Persson F, Andren Y, Winnes M, et al. High-resolution genomic profiling of adenomas and carcinomas in salivary glands reveals amplification, rearrangement, and fusion of HMGA2. Genes Chromosomes Cancer. 2009;48:69–82
  19. Sato K, Ueda Y, Shimasaki M, et al. Pleomorphic adenoma (benign mixed tumor) of the breast: A case report and review of the literature. Pathol Res Pract. 2005;201:333–339
  20. John BJ, Griffiths C, Ebbs SR. Pleomorphic adenoma of the breast should be excised with a cuff of normal tissue. Breast J. 2007;13:418–420
  21. Hayes MM, Lesack D, Gilardet C, et al. Carcinoma ex-pleomorphic adenoma of the breast (Report of three cases suggesting a relationship to metaplastic carcinoma of matrix producing type). Virchows Arch. 2005;446:142–169
  22. Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology. 1991;19:403–410
  23. Di Palma S, Skalova A, Vanìèek T, et al. Non-invasive (intracapsular) carcinoma ex pleomorphic adenoma: Recognition of focal carcinoma by HER-2/neu and MIB1 immunohistochemistry. Histopathology. 2005;46:144–152
  24. Tavassoli FA, Eusebi V. Tumours of the Mammary Gland, Series 4. Washington, DC: Armed Forces Institute of Pathology; 2009;
  25. Lamovec J, Uz-Krazovec M, Zidar A, et al. Adenoid cystic carcinoma of the breast: A histologic, cytologic and immunohistochemical study. Semin Diagn Pathol. 1989;6:153–164
  26. Bauer E, Sumpio E, Jennings TA, et al. Adenoid cystic carcinoma of the breast data from the Connecticut Tumour Registry and a review of the literature. Am J Surg. 1987;205:295–301
  27. Arpino G, Clark GM, Mohsin S, et al. Adenoid cystic carcinoma of the breast (Molecular markers, treatment and clinical outcome). Cancer. 2002;94:2119–2127
  28. Miliauskas JR, Leong AS. Adenoid cystic carcinoma in a juvenile male breast. Pathology. 1991;23:298–301
  29. Okamoto Y, Sumiyama Y, Arima Y, et al. A case of adenoid cystic carcinoma (ACC) of the breast and review of the utility of preoperative imaging diagnose. Breast Cancer. 2001;8:84–89
  30. Gupta RK, Green C, Naran S, et al. Cytology of adenoid cystic carcinoma of the breast. Diagn Cytopathol. 1999;20:82–84
  31. Mastropasqua MG, Maiorano E, Pruneri G, et al. Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast. Mod Pathol. 2005;18:1277–1282
  32. Azoulai A, Lae M, Freneaux P, et al. KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. Mod Pathol. 2005;18:1623–1631
  33. Shin SJ, Rosen PP. Solid variant of mammary adenoid cystic carcinoma with basaloid features: A study of nine cases. Am J Surg Pathol. 2002;26:413–420
  34. Cheuk W, Chan JK, Ngan RK. Dedifferentiation in adenoid cystic carcinoma of salivary gland: An uncommon complication associated with an accelerated clinical course. Am J Surg Pathol. 1999;23:465–472
  35. Chau Y, Hongyo T, Aozasa K, et al. Dedifferentiation of adenoid cystic carcinoma: Report of a case implicating p53 mutation. Hum Pathol. 2001;32:1403–1407
  36. Nagao T, Gaffey TA, Serizawa H, et al. Dedifferentiated adenoid cystic carcinoma: A clinicopathologic study of 6 cases. Mod Pathol. 2003;16:1265–1272
  37. Seethala RR, Hunt JL, Baloch ZW, et al. Adenoid cystic carcinoma with high-grade transformation: A report of 11 cases and a review of the literature. Am J Surg Pathol. 2007;31:1683–1694
  38. Righi A, Morandi L, Lenzi M, et al: Adenoid cystic carcinoma of the breast associated with invasive ductal carcinoma: A case report. Int J Surg Pathol [Epub ahead of print]
  39. Noske A, Schwabe M, Pahl S, et al. Report of a metaplastic carcinoma of the breast with multidirectional differentiation: An adenoid cystic carcinoma, a spindle cell carcinoma and melanoma. Virchows Arch. 2008;452:575–579
  40. Ro JY, Silva EG, Gallager HS. Adenoid cystic carcinoma of the breast. Hum Pathol. 1987;18:1276–1281
  41. Kleer CG, Oberman HA. Adenoid cystic carcinoma of the breast: Value of histologic grading and proliferative activity. Am J Surg Pathol. 1998;22:569–575
  42. Kiaer H, Nielsen B, Paulsen S, et al. Adenomyoepithelial adenosis and low grade malignant adenomyoepithelioma of the breast. Virchows Arch A Pathol Anat Histol. 1984;405:55–67
  43. Eusebi V, Casadei GP, Bussolati G, et al. Adenomyoepitheliom of the breast with a distinctive type of apocrine adenosis. Histopathology. 1987;11:305–315
  44. Tamura G, Monma N, Suzuki Y, et al. Adenomyoepithelioma (myoepithelioma) of the breast in a male. Hum Pathol. 1993;24:678–681
  45. Berna JD, Arcas I, Ballester A, et al. Adenomyoepithelioma of the breast in a male. Am J Roentegnol. 1997;169:917–918
  46. Kurashina M. Fine needle aspiration cytology of benign and malignant adenomyoepithelioma of the breast (Report of two cases). Diagn Cytopathol. 2002;26:29–34
  47. Yahara T, Yamaguchi R, Yokoyama G, et al. Adenomyoepithelioma of the breast diagnosed by a mammotome biopsy: Report of a case. Surg Today. 2008;38:144–146
  48. McLaren BK, Smith J, Schuyler PA, et al. Adenomyoepithelioma clinical, histologic, and immunohistologic evaluation of a series of related lesions. Am J Surg Pathol. 2005;29:1294–1299
  49. Ohi Y, Umekita Y, Rai Y, et al. Clear cell hidradenoma of the breast: A case report and review of the literature. Breast Cancer. 2007;14:307–311
  50. Kazakov DV, Vanecek T, Mukensnabl P, et al. Skin-type hidradenoma of the breast parenchyma with t(11;19) translocation: Hidradenoma of the breast. Am J Dematopathol. 2007;29:457–461
  51. Foschini MP, Pizzicannella G, Peterse JL, et al. Adenomyoepithelioma of the breast associated with low-grade adenosquamous and sarcomatoid carcinomas. Virchows Arch. 1995;427:243–250
  52. Hikino H, Nagaoka S, Miura H, et al. Benign myoepithelioma of the breast: Origin and development. Pathol Int. 2009;59:422–426
  53. Toth J. Benign human mammary myoepithelioma. Virchows Arch A Pathol Anat Histol. 1977;374:263–269
  54. Enghardt MH, Hale JH. An epithelial spindle cell breast tumor of myoepithelial origin (An immunohistochemical and ultrastructural study). Virchows Arch A Pathol Anat Histol. 1989;416:177–184
  55. Tavassoli FA. Myoepithelial lesions of the breast (Myoepitheliosis, adenomyoepithelioma and myoepithelial carcinoma). Am J Surg Pathol. 1991;15:554–568
  56. Lakhani SR, O'Hare MJ, Managhan P, et al. Malignant myoepithelioma (myoepithelial carcinoma) of the breast: A detailed cytokeratin study. J Clin Pathol. 1995;48:164–167
  57. Cartagena N, Cabello-Inchausti B, Willis I, et al. Clear cell myoepithelial neoplasm of the breast. Hum Pathol. 1988;19:1239–1243
  58. Damiani S, Dina RE, Eusebi V. Eosinophilic and granular cell tumors of the breast. Semin Diagn Pathol. 1997;16:117–125
  59. Scarpellini F, Usellini L, Foschini MP. Malignant myoepithelioma associated with ductal carcinoma in situ and invasive (Description of a case and review of the literature). Pathologica. 1997;89:420–424
  60. Jones C, Foschini MP, Chaggar R, et al. Comparative genomic hybridization analysis of myoepithelial carcinoma of the breast. Lab Invest. 2000;80:831–836
  61. Jones C, Nonni AV, Fulford L, et al. CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation. Br J Cancer. 2001;85:422–427
  62. Damiani S, Riccioni L, Pasquinelli G, et al. Poorly differentiated myoepithelial rich cell carcinoma of the breast. Histopathology. 1997;30:542–548
  63. Tsuda H, Tanabe T, Hasegowa T, et al. Myoepithelial differentiation in high grade invasive ductal carcinomas with large central acellular zones. Hum Pathol. 1999;30:1134–1139
  64. Tsuda H, Tanabe T, Hasegowa T, et al. Large central acellular zones indicating myoepithelial tumor differentiation in high grade invasive ductal carcinomas as marker of predisposition to lung and brain metastases. Am J Surg Pathol. 2000;24:197–202
  65. Stewart FW, Foote FW, Becker WF. Muco-epidermoid tumors of salivary glands. Ann Surg. 1945;122:820–844
  66. Patchefsky AS, Frauenhoffer CM, Krall RA. Low-grade mucoepidermoid carcinoma of the breast. Arch Pathol Lab Med. 1979;103:196–198
  67. Camelo-Piragua SI, Habib C, Kanumuri P, et al. Mucoepidermoid carcinoma of the breast share cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: A case report with molecular analysis and review of the literature. Hum Pathol. 2009;40:1887–1892
  68. Horii R, Akiyama F, Ikenaga M, et al. Muco-epidermoid carcinoma of the breast. Pathol Int. 2006;56:549–553
  69. Di Tommaso L, Foschini MP, Ragazzini T, et al. Mucoepidermoid carcinoma of the breast. Virchows Arch. 2004;444:13–19
  70. In:  Tavassoli FA,  Devilee P editor. World Health Organization Classification of Tumours: Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press; 2003;
  71. Rosen PP. Rosen's Breast Pathology. ed 3. Philadelphia, PA: Wolters Kluwer Lippincott Williams & Wilkins; 2009;
  72. Guo SP, Cheuk W, Chan JK. Pleomorphic adenoma with mucinous and squamous differentiation: A mimicker of mucoepidermoid carcinoma. Int J Surg Pathol. 2009;17:335–337
  73. Foschini MP, Marucci G, Eusebi V. Low grade mucoepidermoid carcinoma of salivary glands: Characteristic immunohistochemical profile and evidence of striated duct differentiation. Virchows Arch. 2002;440:536–542
  74. Luchtrach H, Moll R. Mucoepidermoid mammary carcinoma (Immunohistochemical and biochemical analyses of intermediate filaments). Virchows Arch. 1989;416:105–113
  75. O'Neill ID. t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma. Oral Oncol. 2009;45:2–9
  76. Tjalma WA, Verslegers IO, De Loecker PA, et al. Low and high grade mucoepidermoid carcinomas of the breast. Eur J Gynaecol Oncol. 2002;23:423–425
  77. Roncaroli F, Lamovec J, Zidar A, et al. Acinic cell-like carcinoma of the breast. Virchows Arch. 1996;429:69–74
  78. Schmitt FC, Ribeiro CA, Alvarenga S, et al. Primary acinic-cell like carcinoma of the breast—A variant with good prognosis?. Histopathology. 2000;36:286–289
  79. Damiani S, Pasquinelli G, Lamovec J, et al. Acinic cell carcinoma of the breast: An immunohistochemical and ultrastructural study. Virchows Arch. 2000;437:74–81
  80. Coyne JD, Dervon PA. Primary acinic carcinoma of the breast. J Clin Pathol. 2002;55:545–547
  81. Foschini MP, Eusebi V. Rare (new) entities of the breast and medullary carcinoma. Pathology. 2009;41:48–56
  82. Matoso A, Easley SE, Gnepp DR, et al. Salivary gland acinar-like differentiation of the breast. Histopathology. 2009;4:262–263
  83. Lambros MB, Tan DS, Jones RL. Genomic profile of a secretory breast cancer with an ETV6-NTRK3 duplication. J Clin Pathol. 2009;67:604–612
  84. Damiani S, Eusebi V, Losi L, et al. Oncocytic carcinoma (malignant oncocytoma) of the breast. Am J Surg Pathol. 1998;22:221–230
  85. Tremblay G, Pearse AG. A cytochemical study of oxidative enzymes in the parathyroid oxyphil cell and their functional significance. Br J Exp Pathol. 1959;40:66–70
  86. Costa MJ, Silverberg SG. Oncocytic carcinoma of the male breast. Arch Pathol Lab Med. 1989;113:1396–1399
  87. Ragazzi M, Reis-Filho JS, De Biase D, et al. Characterization of oncocytic breast carcinoma (Oral Presentation 22nd Congress European Congress of Pathology). Virchows Archives. 2009;455(suppl 1):S33
  88. Evans HL, Batsakis JG. Polymorphous low-grade adenocarcinoma of minor salivary glands (A study of 14 cases of a distinctive neoplasm). Cancer. 1984;53:935–942
  89. Evans HL, Luna MA. Polymorphous low-grade adenocarcinoma: A study of 40 cases with long-term follow up and an evaluation of the importance of papillary areas. Am J Surg Pathol. 2000;24:1319–1328
  90. Asioli S, Marucci G, Ficarra G, et al. Polymorphous adenocarcinoma of the breast (Report of three cases). Virchows Arch. 2006;448:29–34
  91. Abd El-Rehim DM, Ball G, Pinder SE, et al. High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer. 2005;116:340–350

 This work was partly financed with grants from the University of Bologna (RFO).

PII: S0740-2570(09)00097-5

doi: 10.1053/j.semdp.2009.12.007

Seminars in Diagnostic Pathology
Volume 27, Issue 1 , Pages 77-90 , February 2010

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