Seminars in Diagnostic Pathology
Volume 27, Issue 1 , Pages 31-36 , February 2010

Clinging carcinoma: an American perspective

  • Stuart J. Schnitt, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Stuart J. Schnitt, MD, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215

References 

  1. Azzopardi JG. Problems in Breast Pathology. Philadelphia, PA: WB Saunders; 1979;
  2. Tavassoli FA, Hoefler H, Rosai J, et al. Intraductal proliferative lesions. In:  Tavassoli FA,  Devilee P editor. Pathology and Genetics: Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press; 2003;p. 63–73
  3. Tavassoli FA. Pathology of the Breast. New York, NY: Elsevier; 1992;
  4. Tavassoli FA. Pathology of the Breast. ed 2. Stamford, CT: Appleton and Lange; 1999;
  5. Elston CE, Ellis IO. The Breast. Edinburgh: Churchill Livingstone; 1998;
  6. Page DL, Kasami M, Jensen RA. Hypersecretory hyperplasia with atypia in breast biopsies (What is the proper level of clinical concern?). Pathol Case Rev. 1996;1:36–40
  7. Goldstein NS, O'Malley BA. Cancerization of small ectatic ducts of the breast by ductal carcinoma in situ cells with apocrine snouts: A lesion associated with tubular carcinoma. Am J Clin Pathol. 1997;107:561–566
  8. Fraser J, Raza S, Chorny K, et al. Columnar alteration with prominent apical snouts and secretions: A spectrum of changes frequently present in breast biopsies performed for microcalcifications. Am J Surg Pathol. 1998;22:1521–1527
  9. Tsuchiya S. Atypical ductal hyperplasia, atypical lobular hyperplasia, and interpretation of a new borderline lesion. Jpn J Cancer Clin. 1998;44:548–555
  10. Rosen PP. Columnar cell hyperplasia is associated with lobular carcinoma in situ and tubular carcinoma. Am J Surg Pathol. 1999;23:1561
  11. Oyama T, Maluf H, Koerner F. Atypical cystic lobules: An early stage in the formation of low-grade ductal carcinoma in situ. Virchows Arch. 1999;435:413–421
  12. Moinfar F, Man YG, Bratthauer GL, et al. Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type (“clinging ductal carcinoma in situ”): A simulator of normal mammary epithelium. Cancer. 2000;88:2072–2081
  13. Schnitt SJ, Vincent-Salomon A. Columnar cell lesions of the breast. Adv Anat Pathol. 2003;10:113–124
  14. Schnitt SJ, Collins LC. Biopsy Interpretation of the Breast. Lippincott Williams & Wilkins; 2009;
  15. Pinder SE, Reis-Filho JS. Non-operative breast pathology: Columnar cell lesions. J Clin Pathol. 2007;60:1307–1312
  16. Lerwill MF. Flat epithelial atypia of the breast. Arch Pathol Lab Med. 2008;132:615–621
  17. Moinfar F. Flat ductal intraepithelial neoplasia of the breast: A review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance—it is time to appreciate the Azzopardi concept!. Arch Pathol Lab Med. 2009;133:879–892
  18. Weidner N. Malignant breast lesions that may mimic benign tumors. Semin Diagn Pathol. 1995;12:2–13
  19. Oyama T, Iijima K, Takei H, et al. Atypical cystic lobule of the breast: An early stage of low-grade ductal carcinoma in-situ. Breast Cancer. 2000;7:326–331
  20. Rosen PP. Rosen's Breast Pathology. ed 2. Philadelphia, PA: Lippincott-Raven; 2001;
  21. Eusebi V, Feudale E, Foschini MP, et al. Long-term follow-up of in situ carcinoma of the breast. Semin Diagn Pathol. 1994;11:223–235
  22. Collins LC, Achacoso NA, Nekhlyudov L, et al. Clinical and pathologic features of ductal carcinoma in situ associated with the presence of flat epithelial atypia: An analysis of 543 patients. Mod Pathol. 2007;20:1149–1155
  23. Abdel-Fatah TM, Powe DG, Hodi Z, et al. High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. Am J Surg Pathol. 2007;31:417–426
  24. Brandt SM, Young GQ, Hoda SA. The “rosen triad”: Tubular carcinoma, lobular carcinoma in situ, and columnar cell lesions. Adv Anat Pathol. 2008;15:140–146
  25. Brogi E, Oyama T, Koerner FC. Atypical cystic lobules in patients with lobular neoplasia. Int J Surg Pathol. 2001;9:201–206
  26. Fraser J, Raza S, Chorny K, et al. Immunophenotype of columnar alteration with prominent apical snouts and secretions (CAPSS). Lab Invest. 2000;80:21A
  27. Allred DC, Mohsin SK, Fuqua SA. Histological and biological evolution of human premalignant breast disease. Endocr Relat Cancer. 2001;8:47–61
  28. Dabbs DJ, Kessinger RL, McManus K, et al. Biology of columnar cell lesions in core biopsies of the breast. Mod Pathol. 2003;16:26A
  29. Tremblay G, Deschenes J, Alpert L, et al. Overexpression of estrogen receptors in columnar cell change and in unfolding breast lobules. Breast J. 2005;11:326–332
  30. Lee S, Mohsin SK, Mao S, et al. Hormones, receptors, and growth in hyperplastic enlarged lobular units: Early potential precursors of breast cancer. Breast Cancer Res. 2006;8:R6
  31. Simpson PT, Gale T, Reis-Filho JS, et al. Columnar cell lesions of the breast: The missing link in breast cancer progression? A morphological and molecular analysis. Am J Surg Pathol. 2005;29:734–746
  32. Dessauvagie BF, Zhao W, Heel-Miller KA, et al. Characterization of columnar cell lesions of the breast: Immunophenotypic analysis of columnar alteration of lobules with prominent apical snouts and secretions. Hum Pathol. 2007;38:284–292
  33. Dabbs DJ, Carter G, Fudge M, et al. Molecular alterations in columnar cell lesions of the breast. Mod Pathol. 2006;19:344–349
  34. Abdel-Fatah TM, Powe DG, Hodi Z, et al. Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: Further evidence to support the concept of low nuclear grade breast neoplasia family. Am J Surg Pathol. 2008;32:513–523
  35. Bijker N, Peterse JL, Duchateau L, et al. Risk factors for recurrence and metastasis after breast-conserving therapy for ductal carcinoma-in-situ: Analysis of European Organization for Research and Treatment of Cancer trial 10853. J Clin Oncol. 2001;19:2263–2271
  36. de Mascarel I, MacGrogan G, Picot V, et al. Results of a long term follow-up study of 115 patients with flat epithelial atypia. Lab Invest. 2006;86(suppl 1):25A
  37. Martel M, Barron-Rodriguez P, Tolgay Ocal I, et al. Flat DIN 1 (Flat epithelial atypia) on core needle biopsy: 63 Cases identified retrospectively among 1,751 core biopsies performed over an 8-year period (1992-1999). Virchows Arch. 2007;451:883–891

PII: S0740-2570(09)00096-3

doi: 10.1053/j.semdp.2009.12.006

Seminars in Diagnostic Pathology
Volume 27, Issue 1 , Pages 31-36 , February 2010