Seminars in Diagnostic Pathology
Volume 26, Issue 1 , Pages 49-52 , February 2009

Laboratory interferences with the newer cyanide antidote: hydroxocobalamin

  • Nathan Beckerman, MD

      Affiliations

    • Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington
    • ,
  • Scott M. Leikin

      Affiliations

    • Center for Simulation Technology and Academic Research (CSTAR), Northshore University HealthSystem, Evanston/Highland Park Hospitals, Evanston, Illinois
    • ,
  • Robert Aitchinson

      Affiliations

    • Center for Simulation Technology and Academic Research (CSTAR), Northshore University HealthSystem, Evanston/Highland Park Hospitals, Evanston, Illinois
    • ,
  • May Yen, MD

      Affiliations

    • Department of Emergency Medicine, Northwestern Memorial Hospital, Chicago, Illinois
    • ,
  • Brandon K. Wills, DO, MS

      Affiliations

    • Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington
    • Washington Poison Center, Seattle, Washington
    • Corresponding Author InformationAddress reprint requests and correspondence: Brandon K. Wills, DO, MS, Department of Emergency Medicine, Madigan Army Medical Center, Building 9040, Fitzsimmons Drive, Tacoma, WA 98431

References 

  1. Morocco A. Cyanides. Crit Care Clin. 2005;21:691–705
  2. Baud FJ, Borron SW, Megarbane B, et al. Value of lactic acidosis in the assessment of the severity of acute cyanide poisoning. Crit Care Med. 2002;30:2044–2050
  3. Barratt-Boyes BG, Wood EH. The oxygen saturation of blood in the venae cavae, right-heart chambers, and pulmonary vessels of healthy subjects. J Lab Clin Med. 1957;50:93–106
  4. Johnson RP, Mellors JW. Arteriolization of venous blood gases: a clue to the diagnosis of cyanide poisoning. J Emerg Med. 1988;6:401–404
  5. Wills B. Venous blood oxygen saturation. Arch Surg. 2006;141:716
  6. Hall AH, Rumack BH. Clinical toxicology of cyanide. Ann Emerg Med. 1986;15:1067–1074
  7. Scolnick B, Hamel D, Woolf AD. Successful treatment of life-threatening propionitrile exposure with sodium nitrite/sodium thiosulfate followed by hyperbaric oxygen. J Occup Med. 1993;35:577–580
  8. Borron SW, Baud FJ, Barriot P, et al. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg Med. 2007;49:794–801
  9. Fortin JL, Giocanti JP, Ruttimann M, et al. Prehospital administration of hydroxocobalamin for smoke inhalation-associated cyanide poisoning: 8 years of experience in the Paris Fire Brigade. Clin Toxicol (Phila). 2006;44(suppl 1):37–44
  10. Cyanokit. [package insert] Napa, CA: Dey, L.P; 2007;
  11. Hall AH, Dart R, Bogdan G. Sodium thiosulfate or hydroxocobalamin for the empiric treatment of cyanide poisoning?. Ann Emerg Med. 2007;49:806–813
  12. Curry SC, Connor DA, Raschke RA. Effect of the cyanide antidote hydroxocobalamin on commonly ordered serum chemistry studies. Ann Emerg Med. 1994;24:65–67
  13. Vest P, Renaudeau C, Tellal S, et al. Interference of hydroxocobalamine treatment on commun biochemical determinations. Ann Biol Clin (Paris). 2002;60:57–64
  14. Beaudeux JL, Flourie F, Peynet J, et al. Hydroxocobalamin and sodium thiosulfate interfere negatively with measurement of creatine kinase activity. Clin Chem. 1994;40:2120–2121
  15. Lee J, Mukai D, Kreuter K, et al. Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatments. Ann Emerg Med. 2007;49:802–805
  16. Denninghoff K, Walter FG, Langa AJ, et al. Spectrophotometry of hydroxocobalamin and hemoglobin reveals production of an unanticipated methemoglobin variant. Clin Toxicol (Phila). 2008;46:545–550

PII: S0740-2570(08)00119-6

doi: 10.1053/j.semdp.2008.12.008

Seminars in Diagnostic Pathology
Volume 26, Issue 1 , Pages 49-52 , February 2009

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