Seminars in Diagnostic Pathology
Volume 26, Issue 1 , Pages 49-52, February 2009

Laboratory interferences with the newer cyanide antidote: hydroxocobalamin

  • Nathan Beckerman, MD

      Affiliations

    • Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington
    • ,
  • Scott M. Leikin

      Affiliations

    • Center for Simulation Technology and Academic Research (CSTAR), Northshore University HealthSystem, Evanston/Highland Park Hospitals, Evanston, Illinois
    • ,
  • Robert Aitchinson

      Affiliations

    • Center for Simulation Technology and Academic Research (CSTAR), Northshore University HealthSystem, Evanston/Highland Park Hospitals, Evanston, Illinois
    • ,
  • May Yen, MD

      Affiliations

    • Department of Emergency Medicine, Northwestern Memorial Hospital, Chicago, Illinois
    • ,
  • Brandon K. Wills, DO, MS

      Affiliations

    • Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington
    • Washington Poison Center, Seattle, Washington
    • Corresponding Author InformationAddress reprint requests and correspondence: Brandon K. Wills, DO, MS, Department of Emergency Medicine, Madigan Army Medical Center, Building 9040, Fitzsimmons Drive, Tacoma, WA 98431

Cyanide poisoning occurs in many smoke inhalation victims. The newest FDA-approved treatment for acute cyanide intoxication is hydroxocobalamin (Cyanokit®). However, hydroxocobalamin exhibits chemical properties that can disrupt several clinical laboratory tests. Knowledge of these effects on laboratory tests can be useful in assisting laboratory technicians and clinicians in managing these patients. This article briefly discusses acute cyanide poisoning and treatment, and summarizes laboratory interferences that have been reported with the use of hydroxocobalamin.

Keywords: Cyanide, Cyanokit®, Hyrdoxocobalamin, Toxicity, Laboratory

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PII: S0740-2570(08)00119-6

doi:10.1053/j.semdp.2008.12.008

Seminars in Diagnostic Pathology
Volume 26, Issue 1 , Pages 49-52, February 2009

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