« Previous
Next »
Seminars in Diagnostic Pathology
Volume 25, Issue 4
, Pages 262-273
, November 2008
Targeted therapies in gynecologic cancers and melanoma
References
- Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas. Cancer Res. 2003;63:5697–5702
- . Two pathogenetic types of endometrial carcinoma. Gynecol Oncol. 1983;15:10–17
- . A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses. Verh Dtsch Ges Pathol. 1997;81:228–232
- Molecular pathology of endometrial hyperplasia and carcinoma. Hum Pathol. 2001;32:569–577
- Microsatellite instability in endometrial carcinomas clinicopathologic correlations in a series of 42 cases. Human Pathol. 1998;29:1160–1164
- PTEN mutations in endometrial carcinomas (A molecular and clinicopathologic analysis of 38 cases). Hum Pathol. 2000;31:312–317
- PIK3CA gene mutations in endometrial carcinoma: correlation with PTEN and K-RAS alterations. Hum Pathol. 2006;37:1465–1472
- CTNNB1 mutations and beta-catenin expression in endometrial carcinomas. Hum Pathol. 2002;33:206–212
- Abnormalities of the APC/beta-catenin pathway in endometrial cancer. Oncogene. 2002;21:7981–7990
- p53 gene mutations are common in uterine serous carcinoma and occurs early in their pathogenesis. Am J Pathol. 1997;150:177–185
- . p53 in endometrial cancer and its putative precursors: evidence for diverse pathways of tumorigenesis. Hum Pathol. 1995;26:1268–1274
- Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst. 2000;92:924–931
- PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma. Cancer Res. 1998;58:3254–3258
- High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res. 2005;65:10669–10673
- Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. Int J Oncol. 2003;23:803–810
- . Targeted therapies in gynecologic cancers. Curr Cancer Drug Targets. 2006;6:333–363
- An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice. Proc Natl Acad Sci U S A. 2001;98:10320–10325
- Prognostic utility of epidermal growth factor receptor overexpression in endometrial adenocarcinoma. Cancer. 1994;73:370–376
- HER-2 is an independent prognostic factor in endometrial cancer: association with outcome in a large cohort of surgically staged patients. J Clin Oncol. 2006;24:2376–2385
- Abnormalities in NF-kB family and related proteins in endometrial carcinoma (A tissue microarray study). J Pathol. 2004;13:569–577
- BAX somatic frameshift mutations in endometrioid adenocarcinomas of the endometrium: evidence for a tumor progression role in endometrial carcinomas with microsatellite instability. Lab Invest. 1998;78:1439–1444
- Proteasome inhibitors induce death but activate NF-kappaB on endometrial carcinoma cell lines and primary culture explants. J Biol Chem. 2006;281:22118–22130
- Antioxidants block proteasome inhibitor function in endometrial carcinoma cells. Anticancer Drugs. 2008;19:115–124
- FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis. Lab Invest. 2005;85:885–894
- CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells. Oncogene. 2008;27:2513–2524
- . Effects of histone deacetylase inhibitors on estradiol-induced proliferation and hyperplasia formation in the mouse uterus. J Endocrinol. 2005;185:539–549
- Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. Clin Cancer Res. 2004;10:1141–1149
- . Molecular pathology of ovarian carcinomas. Virchows Arch. 1998;433:103–111
- . Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications. Int J Gynecol Pathol. 2008;27:151–160
- Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst. 2000;92:564–569
- Loss of heterozygosity on chromosome 13q12-q14, BRCA-2 mutations and lack of BRCA-2 promoter hypermethylation in sporadic epithelial ovarian tumors. Cancer. 2001;92:787–795
- Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors. Cancer. 2001;92:2829–2836
- Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. Am J Pathol. 2003;163:2503–2512
- K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases. Cancer. 1997;79:1581–1586
- Phase II trial of bevacizumab in persisntent or recurrent epithelail ovarian cancer or primary peritoneal cancer (A Gynecologic Oncology Group study (abstract)). J Clin Oncol. 2005;23:457s
- . The emerging role of epidermal growth factor receptor inhibitors in ovarian cancer. Int J Gynecol Cancer. 2007;Dec 5 [Epub ahead of print]
- Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology Group. J Clin Oncol. 2003;21:283–290
- Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status. J Clin Oncol. 2006;24:4324–4332
- Molecular targeting of BCL2 and BCLXL proteins by synthetic BCL2 homology 3 domain peptide enhances the efficacy of chemotherapy. J Pharmacol Exp Ther. 2006;316:992–998
- Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib. Eur J Cancer. 2007;43:55–63
- . Genetic pathways to melanoma tumorogenesis. J Clin Pathol. 2004;57:797–801
- . Genetics: what advice for patients who present with a family history of melanoma?. Semin Oncol. 2007;34:452–459
- Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353:2135–2147
- Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006;24:4340–4346
- . Cutaneous melanoma. Lancet. 2005;365:687–701
- . Systemic therapy for metastatic malignant melanoma–from deeply disappointing to bright future?. Exp Dermatol. 2008;17:383–394
- . The MAPK pathway in melanoma. Curr Opin Oncol. 2008;20:183–189
- . The role of B-RAF in melanoma. Cancer Metastasis Rev. 2005;24:165–183
- The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells. Cancer Res. 2006;66:1611–1619
- Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer. 2006;95:581–586
- Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group. J Clin Oncol. 2008;26:2178–2185
- BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin. Mol Cancer Ther. 2005;4:1303–1310
- . Functional and therapeutic significance of Akt deregulation in malignant melanoma. Cancer Metastasis Rev. 2005;24:273–285
- . Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br J Cancer. 2004;91:1420–1424
- Antiproliferative effect of STI571 on cultured human cutaneous melanoma-derived cell lines. Melanoma Res. 2006;16:127–135
- . Imatinib mesylate for melanoma: will a new target be revealed?. J Invest Dermatol. 2004;123:xi–xiii
- Roles of stem cell factor/c-kit and effects of Glivec(R)/STI571 in human uveal melanoma cell tumorigenesis. J Biol Chem. 2004;23:31769–31779
- Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE. PS-341) as a therapeutic agent for malignant melanoma. Cancer Res. 2004;64:4912–4918
- Effect of proteasome inhibitors on proliferation and apoptosis of human cutaneous melanoma-derived cell lines. Br J Dermatol. 2008;158:496–504
- Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group. J Clin Oncol. 2006;24:4738–4745
- . Bcl-2-targeted antisense therapy (Oblimersen sodium): towards clinical reality. Rev Recent Clin Trials. 2006;1:217–235
- . Oblimersen in the treatment of metastatic melanoma. Future Oncol. 2007;3:263–271
- A randomized phase 2 trial of bevacizumab with or without daily low-dose interferon alfa-2b in metastatic malignant melanoma. Ann Surg Oncol. 2007;14:2367–2376
- . Tremelimumab, a fully human monoclonal IgG2 antibody against CTLA4 for the potential treatment of cancer. Curr Opin Mol Ther. 2007;9:505–514
- . Anti-CTLA4 monoclonal antibody ipilimumab in the treatment of metastatic melanoma: recent findings. Recent Patents Anticancer Drug Discov. 2008;3:105–113
- Expression of somatostatin receptors (SSTR) in melanoma cell lines (Effect of somatostatin analogues on their proliferation). Arch Dermatol Res. 2007;299:290
PII: S0740-2570(08)00062-2
doi: 10.1053/j.semdp.2008.07.008
© 2008 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Diagnostic Pathology
Volume 25, Issue 4
, Pages 262-273
, November 2008
