Seminars in Diagnostic Pathology
Volume 25, Issue 3 , Pages 147-153 , August 2008

The benign versus malignant paradigm in oncologic pathology: a critique

  • Juan Rosai, MD

      Affiliations

    • Centro Diagnostico Italiano, Milan, Italy
    • Genzyme Corporation, New York, New York
    • Corresponding Author InformationAddress for correspondence: Juan Rosai, MD, Centro Consulenze Anatomia Patologica Oncologica, Centro Diagnostico Italiano (CDI), Via Saint Bon,20, 20147 Milano, Italy

References 

  1. Hayakawa SI, Haykawa AR. Language in Thought and Action. (ed 5). San Diego, CA, Harcourt: Brace & Company; 1990;112, 127
  2. Virchow R. Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre. (ed 5). Berlin: Verlag von August Hirschwald; 1871;
  3. Stout AP. Introduction. In: Proceedings of the Arthur Purdy Stout Society Seminar. New York, NY: Columbia–Presbyterian Medical Center; 1967;p. 3;June 10
  4. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61:759–767
  5. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100:57–70
  6. Thompson LD, Wieneke JA, Paal E, et al. A clinicopathologic study of minimally invasive follicular carcinoma of the thyroid gland with a review of the English literature. Cancer. 2001;91:505–524
  7. Van Heerden JA, Hay ID, Goellner JR, et al. Follicular thyroid carcinoma with capsular invasion alone: a nonthreatening malignancy. Surgery. 1992;112:1130–1136
  8. Paniago-Pereira C, Maize JC, Ackerman AB. Nevus of large spindle and/or epithelioid cells (Spitz's nevus). Arch Dermatol. 1978;114:1811–1823
  9. Busam KJ, Barnhill RL. Pagetoid Spitz nevus (Intraepidermal Spitz tumor with prominent pagetoid spread). Am J Surg Pathol. 1995;19:1061–1067
  10. Howat AJ, Variend S. Lymphatic invasion in Spitz nevi. Am J Surg Pathol. 1985;9:125–128
  11. Gambini C, Rongioletti F. Recurrent Spitz nevus (Case report and review of the literature). Am J Dermatopathol. 1994;16:409–413
  12. Goldes J, Holmes S, Satz M, et al. Melanoma masquerading as Spitz nevus following acute lymphoblastic leukaemia. Pediatr Dermatol. 1984;1:295–298
  13. Swerlick RA, Chen S. The melanoma epidemic: more apparent than real?. Mayo Clin Proc. 1997;72:559–564
  14. Koh HK, Geller AC, Miller DR, et al. Who is being screened for melanoma/skin cancer? (Characteristics of persons screened in Massachusetts). J Am Acad Dermatol. 1991;24:271–277
  15. Allsbrook WC, Mangold KA, Johnson MH, et al. Interobserver reproducibility of Gleason grading of prostatic carcinoma: general pathologists. Hum Pathol. 2001;32:81–88
  16. Lloyd RV, Erickson LA, Casey MB, et al. Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma. Am J Surg Pathol. 2004;28:1336–1340
  17. Rosai J. Borderline epithelial lesions of the breast. Am J Surg Pathol. 1991;15:209–221
  18. Foucar E. Carcinoma-in-situ of the breast: have pathologists run amok?. Lancet. 1996;347:707–708
  19. Kramer IRH, Pindborg JJ, Shear M. Histological typing of odontogenic tumours, in World Health Organization: International Histological Classification of Tumours (ed 2). Berlin: Springer-Verlag; 1992;
  20. Schajowicz F. Histological typing of bone tumours. In: World Health Organization: International Histological Classification of Tumours. (ed 2). Berlin: Springer-Verlag; 1993;p. 35
  21. Sakorafas GH, Sarr MG. Local excision of periampullary villous tumours of the duodenum. Eur J Surg Oncol. 1999;25:90–93
  22. Young RH, Scully RE. Villoglandular papillary adenocarcinoma of the uterine cervix (A clinicopathologic analysis of 13 cases). Cancer. 1989;63:1773–1779
  23. Weiss LM. Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol. 1984;8:163–169
  24. Aubert S, Wacreiner A, Leroy X, et al. Weiss system revisited: a clinicopathologic and immunohistochemical study of 49 adrenocortical tumors. Am J Surg Pathol. 2002;26:1612–1619
  25. Kempson RL, Hendrickson MR. Ovarian serous borderline tumors: the citadel defended. Hum Pathol. 2000;31:525–526
  26. Park WW, Corkhill JW. Preface. The Histology of Borderline Cancer: With Notes on Prognosis. Berlin: Springer-Verlag; 1980;
  27. Kindblom LG, Angervall L, Fassina AS. Atypical lipoma. Acta Pathol Microbiol Immunol Scand. 1982;90A:27–36
  28. Enzinger FM, Winslow DJ. Liposarcoma (A study of 103 cases). Virchows Arch Pathol Anat. 1962;335:367–388
  29. Evans HL. Liposarcomas and atypical lipomatous tumors: a study of 66 cases followed for a minimum of 10 years. Surg Pathol. 1988;1:41–54
  30. Kempson RL. Sarcomas and related neoplasms. In:  Norris HJ,  Hertig AT,  Abell MR editor. The Uterus. Baltimore, MD: The Williams and Wilkins Co; 1973;p. 302–303
  31. Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasms: a clinicopathologic study of 213 cases. Am J Surg Pathol. 1994;18:535–558
  32. Reuter VR, Epstein Ji, Amin MA, et al. A newly illustrated synopsis of the World Health Organization/International Society of Urological Pathology (WHO/ISUP) consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. J Urol Pathol. 1999;11:1–28
  33. Williams ED Chernobyl Pathologists group. Two proposals regarding the terminology of thyroid tumors. Int J Surg Pathol. 2000;8:181–184
  34. Serov SF, Scully RE, Sobin LH. Histological typing of ovarian tumours. In: Fascicle no. 9 of International Histological Classification of Tumours. Geneva: World Health Organization; 1973;p. 17
  35. Taylor HC. Malignant and semimalignant tumors of the ovary. Surg Gynecol Obstet. 1929;48:204–230
  36. Seidman JD, Kurman RJ. Subclassification of serous borderline tumors of the ovary into benign and malignant types (A clinicopathologic study of 65 advanced stage cases). Am J Surg Pathol. 1996;20:1331–1345
  37. Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Int J Surg Pathol. 2002;10:81–89
  38. Corless CL. Assessing the prognosis of gastrointestinal stromal tumors (A growing role for molecular testing). Am J Clin Pathol. 2004;122:11–13

PII: S0740-2570(08)00056-7

doi: 10.1053/j.semdp.2008.07.002

Seminars in Diagnostic Pathology
Volume 25, Issue 3 , Pages 147-153 , August 2008

Article Tools

* Image Usage & Resolution