Seminars in Diagnostic Pathology
Volume 25, Issue 1 , Pages 69-75 , February 2008

The management of malignant cardiac tumors: clinical considerations

  • Charles Catton, MD, FRCPC

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Charles Catton, MD, FRCPC, Room 5-991, 610 University Avenue, Toronto, Canada, M5G 2M9.

References 

  1. Lam K, Dickens P, Chan A. Tumors of the heart (A 20-year experience with a review of 12,485 consecutive autopsies). Arch Pathol Lab Med. 1993;117:1027–1031
  2. Odim J, Reehal V, Laks H, et al. Surgical pathology of cardiac tumors (Two decades at an urban institution). Cardiovasc Pathol. 2003;12:267–270
  3. Centofanti P, Di Rosa E, Deorsola L, et al. Primary cardiac tumors: early and late results of surgical treatment in 91 patients. Ann Thorac Surg. 1999;68:1236–1241
  4. Takach T, Reul G, Ott D, et al. Primary cardiac tumors in infants and children: immediate and long-term operative results. Ann Thorac Surg. 1996;62:559–564
  5. Thomas-de-Montpréville V, Nottin R, Dulmet E, et al. Heart tumors in children and adults: clinicopathological study of 59 patients from a surgical center. Cardiovasc Pathol. 2007;16:22–28
  6. Kamiya H, Yasuda T, Nagamine H, et al. Surgical treatment of primary cardiac tumors: 28 years’ experience in Kanazawa University Hospital. Jpn Circ J. 2001;65:315–319
  7. Kajihara N, Tanoue Y, Eto M, et al. Surgical experience of cardiac tumors: early and late results. Surg Today. 2006;36:602–607
  8. Piazza N, Chughtai T, Toledano K, et al. Primary cardiac tumours: eighteen years of surgical experience on 21 patients. Can J Cardiol. 2004;20:1443–1448
  9. Abraham K, Reddy V, Gattuso P. Neoplasms metastatic to the heart: review of 3314 consecutive autopsies. Am J Cardovasv Pathol. 1990;3:195–198
  10. MacGee W. Metastatic and invasive tumours involving the heart in a geriatric population: a necropsy study. Virchows Arch A Pathol Anat Histopathol. 1991;419:183–189
  11. Silvestri F, Bussani R, Pavletic N, et al. Metastases of the heart and pericardium. G Ital Cardiol. 1997;27:1252–1255
  12. Butany J, Leong S, Carmichael K, et al. A 30-year analysis of cardiac neoplasms at autopsy. Can J Cardiol. 2005;21:675–680
  13. Rannikko A, Sipponen J, Nordling S, et al. Cavoatrial extension of renal cell cancer: results of operative treatment in Helsinki University Hospital between 1990 and 2000. Scand J Surg. 2004;93:213–216
  14. Kieffer E, Alaoui M, Piette J, et al. Leiomyosarcoma of the inferior vena cava: experience in 22 cases. Ann Surg. 2006;244:289–295
  15. Moorjani N, Kuo J, Ashley S, et al. Intravenous uterine leiomyosarcomatosis with intracardial extension. J Card Surg. 2005;20:382–385
  16. Uemura M, Sasaki Y, Yamada T, et al. Surgery for hepatocellular carcinoma with tumor thrombus extending into the right atrium: report of a successful resection without the use of cardiopulmonary bypass. Hepatogastroenterology. 2004;51:1259–1262
  17. Chuah K, Yap W, Loh H, et al. Intravenous extension of sarcomatoid carcinoma of the lung to the left atrium. Pathology. 2006;38:359–361
  18. Hoffstetter P, Djavidani B, Feuerbach S, et al. Myxoid fibrosarcoma of a pulmonary vein with extension into the left atrium. AJR Am J Roentgenol. 2006;186:365–367
  19. Chrissos D, Stougiannos P, Mytas D, et al. Multiple cardiac metastases from a malignant melanoma. Eur J Echocardiogr. 2007;Mar 6 (Epub ahead of print)
  20. Minicucci M, Zornoff L, Okoshi M, et al. Heart failure due to right ventricular metastatic neuroendocrine tumor. Int J Cardiol. 2007;Mar 28 (Epub ahead of print)
  21. Jo J, Lee D, Kang B, et al. Both-sided intra-atrial intracardiac metastases as the initial presentation of testicular seminoma. Jpn J Clin Oncol. 2007;37:463–468
  22. Kadono Y, Yamamoto H, Tajika E. Cardiac metastasis from a transitional cell carcinoma diagnosed by two-dimensional echocardiography. Int J Urol. 2006;13:454–456
  23. Atik F, Navia J, Krishnamurthi V, et al. Solitary massive right ventricular metastasis of renal cell carcinoma without inferior vena cava or right atrium involvement. J Card Surg. 2006;21:304–306
  24. Moreno-Vega A, Fuentes-Pradera J, Gordón-Santiago M, et al. Intraventricular metastases from rectal-sigmoid adenocarcinoma. Clin Transl Oncol. 2006;8:296–297
  25. Bowman A, Siegel R, Blanche C, et al. Metastatic pancreatic adenocarcinoma to the heart diagnosed antemortem. J Am Soc Echocardiogr. 2000;13:415–416
  26. Feys A, Herregods M, Ector H. Cardiac metastasis from a stage IIIb cervix carcinoma. Acta Cardiol. 2005;60:73–75
  27. Nakamura Y, Nakano K, Gomi A, et al. A metastatic ball tumor in the right atrium originating from esophageal cancer: report of a case. Surg Today. 2005;35:145–148
  28. Daher I, Luh J, Duarte A. Squamous cell lung cancer simulating an acute myocardial infarction. Chest. 2003;123:304–306
  29. Inoue T, Shiraki K, Fuke H, et al. Cardiac metastases of gallbladder carcinoma. World J Gastroenterol. 2005;11:2048–2049
  30. Giuffrida D, Gharib H. Cardiac metastasis from primary anaplastic thyroid carcinoma: report of three cases and a review of the literature. Endocr Relat Cancer. 2001;8:71–73
  31. Mazzoccoli G, Carughi S, La Viola M, et al. Cardiac metastasis of poorly differentiated adenocarcinoma of unknown primary site. Ital Heart J Suppl. 2002;2002:1112–1116
  32. Meng Q, Lai H, Lima J, et al. Echocardiographic and pathological characteristics of cardiac metastasis in patients with lymphoma. Oncol Rep. 2002;9:85–88
  33. Goddard M, Atkinson C. Cardiac metastasis from a bronchial carcinoid: report of a case presenting with diffuse thickening of the left ventricular wall. J Clin Pathol. 2004;57:778–779
  34. Faingold R, Babyn P, Yoo S, et al. Neuroblastoma with atypical metastases to cardiac and skeletal muscles: MRI features. Pediatr Radiol. 2003;33:584–586
  35. Recchia F, Saggio G, Amiconi G, et al. Cardiac metastases in malignant fibrous histiocytoma (A case report). Tumori. 2006;92:76–78
  36. Chandramohan N, Hussain M, Nayak N, et al. Multiple cardiac metastases from Ewing’s sarcoma. Can J Cardiol. 2005;21:525–527
  37. Miralles A, Bracamonte L, Soncul H, et al. Cardiac tumors: clinical experience and surgical results in 74 patients. Thorac Surg. 1991;52:886–895
  38. Kosuga T, Fukunaga S, Kawara T, et al. Surgery for primary cardiac tumors (Clinical experience and surgical results in 60 patients). J Cardiovasc Surg (Torino). 2002;43:581–587
  39. Mocini D, Longo R, Colivicchi F, et al. A complete atrioventricular block secondary to myocardial metastases of lung cancer (A case report). Ital Heart J. 2005;6:931–932
  40. Schumann C, Kunze M, Kochs M, et al. Pericardial synovial sarcoma mimicking pericarditis in findings of cardiac magnetic resonance imaging. Int J Cardiol. 2007;118:83–84
  41. Lorbar M, Spodick D. “Idiopathic” pericarditis: the clinician’s challenge. [nothing is idiopathic] Int J Clin Pract. 2007;61:138–142
  42. Borsaru A, Lau K, Solin P. Cardiac metastasis: a cause of recurrent pulmonary emboli. Br J Radiol. 2007;80:50–53
  43. Jassal D, Thakrar A, Neilan T, et al. Cardioembolic stroke in a patient with spindle cell sarcoma of the left atrium. J Am Soc Echocardiogr. 2007;20:1–4
  44. Mailapur R, Khaneja S, Schein M, et al. Intractable obstructive shock as a result of isolated cardiac metastases: a case report. Int Surg. 2001;86:198–200
  45. Balghith M, Taylor D, Jugdutt B. Cardiac tamponade as the first clinical manifestation of metastatic adenocarcinoma of the lung. Can J Cardiol. 2000;16:925–927
  46. Mazzola A, Spano J, Valente M, et al. Leiomyosarcoma of the left atrium mimicking a left atrial myxoma. J Thorac Cardiovasc Surg. 2006;131:224–226
  47. Glazer M, Kioschos J, Kroetz F, et al. Simulation of right atrial myxoma by metastatic leiomyosarcoma. Cancer. 1971;37:238–241
  48. O’Sullivan B, Wylie J, Catton C, et al. The local management of soft tissue sarcoma. Semin Radiat Oncol. 1999;9:328–348
  49. O’Sullivan B, Pisters P. Staging and prognostic factor evaluation in soft tissue sarcoma. Surg Oncol Clin North Am. 2003;12:333–353
  50. Lewis J, Leung D, Woodruff J, et al. Retroperitoneal soft-tissue sarcoma: an analysis of 500 patients treated and followed at a single institution. Ann Surg. 1998;228:355–365
  51. Le Vay J, O’Sullivan B, Catton C, et al. An assessment of prognostic factors in soft-tissue sarcoma of the head and neck. Arch Otolaryngol Head Neck Surg. 1994;120:981–9861994
  52. Swallow C, Catton C. Local management of adult soft tissue sarcomas. Semin Oncol. 2007;34:256–259
  53. O’Sullivan B, Gullane P, Irish J, et al. Preoperative radiotherapy for adult head and neck soft tissue sarcoma: assessment of wound complication rates and cancer outome in a prospective series. World J Surg. 2003;27:875–883
  54. Jones J, Catton C, O’Sullivan B, et al. Initial results of a trial of pre-operative external beam radiation therapy and post-operative brachytherapy for retroperitoneal sarcoma. Ann Surg Oncol. 2002;9:324–325
  55. Pisters P, Harrison L, Leung D, et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 1996;14:859–868
  56. Yang J, Chang A, Baker A, et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 1998;16:197–203
  57. O’Sullivan B, Davis A, Turcotte R, et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet. 2002;359:2235–2241
  58. Sarcoma Meta-analysis Collaboration. Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Lancet. 1997;350:1647–1654
  59. Reardon M, Walkes J-C, Benjamin R. Therapy insight: malignant primary cardiac tumors. Nature Clin Pract. 2006;3:548–553
  60. Shanmugam G. Primary cardiac sarcoma. Eur J Cardiothorac Surg. 2006;29:925–932
  61. Restrepo C, Largoza A, Lemos D, et al. CT and MR imaging findings of malignant cardiac tumors. Curr Probl Diagn Radiol. 2005;34:1–11
  62. Wann L, Sampson C, Liu Y. Cardiac and paracardiac masses: complementary role of echocardiography and magnetic resonance imaging. Echocardiography. 1998;15:139–146
  63. van Beek E, Stolpen A, Khanna G, et al. CT and MRI of pericardial and cardiac neoplastic disease. Cancer Imaging. 2007;7:19–26
  64. Hoffmeier A, Schmid C, Deiters S, et al. Neoplastic heart disease: the Muenster experience with 108 patients. Thorac Cardiovasc Surg. 2005;53:1–8
  65. Hoffmeier A, Deiters S, Schmidt C, et al. Radical resection of cardiac sarcoma. Thorac Cardiovasc Surg. 2004;52:77–81
  66. Rodríguez-Cruz E, Cintrón-Maldonado R, Forbes T. Treatment of primary cardiac malignancies with orthotopic heart transplantation. Bol Asoc Med P R. 2000;92:65–71
  67. Goldstein D, Oz M, Rose E, et al. Experience with heart transplantation for cardiac tumors. J Heart Lung Transplant. 1995;14:382–386
  68. Reece I, Cooley D, Frazier O, et al. Cardiac tumors (Clinical spectrum and prognosis of lesions other than classical benign myxoma in 20 patients). J Thorac Cardiovasc Surg. 1984;88:439–446
  69. Bossert T, Gummert J, Battellini R, et al. Surgical experience with 77 primary cardiac tumors. Interact Cardiovasc Thorac Surg. 2005;4:311–315
  70. Kubota H, Takamoto S, Kotsuka Y, et al. Surgical treatment of malignant tumors of the right heart. Jpn Heart J. 2002;43:263–271
  71. Park B, Bacchetta M, Bains M, et al. Surgical management of thoracic malignancies invading the heart or great vessels. Ann Thorac Surg. 2004;78:1024–1030
  72. Harting M, Messner G, Gregoric I, et al. Sarcoma metastatic to the right ventricle: surgical intervention followed by prolonged survival. Tex Heart Inst J. 2004;31:93–95
  73. Agarwal V, Agarwal S, Srivastava A, et al. Primary cardiac tumors: surgical experience and follow-up. Indian Heart J. 2003;55:632–636
  74. Santoro A, Tursz T, Mouridsen H, et al. Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol. 1995;13:1537–1545
  75. Antman K, Crowley J, Balcerzak S, et al. An intergroup phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J Clin Ocol. 1993;11:1276–1285
  76. Edmonson J, Ryan L, Blum R, et al. Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplain against advanced soft tissue sarcomas. J Clin Ocol. 1993;11:12691175

PII: S0740-2570(07)00103-7

doi: 10.1053/j.semdp.2007.10.007

Seminars in Diagnostic Pathology
Volume 25, Issue 1 , Pages 69-75 , February 2008

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