Seminars in Diagnostic Pathology
Volume 25, Issue 1 , Pages 29-38 , February 2008

Cardiac tumors of adipocytes and cystic tumor of the atrioventricular node

  • John P. Veinot, MD, FRCPC

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: John P. Veinot, MD, FRCPC, Department of Laboratory Medicine, Room 123, Ottawa Hospital, Civic Campus, 1053 Carling Ave, Ottawa, Ontario, Canada, K1Y 4E9.

References 

  1. Prior JT. Lipomatous hypertrophy of the cardiac interatrial septum (A lesion resembling hibernoma, lipoblastomatosis and infiltrating lipoma). Arch Pathol. 1964;78:11–15
  2. Isner JM, Swan CS, Mikus JP, et al. Lipomatous hypertrophy of the interatrial septum: in vivo diagnosis. Circulation. 1982;66:470–473
  3. Pharr JR, Figueredo VM. Lipomatous hypertrophy of the atrial septum and prominent crista terminalis appearing as a right atrial mass. Eur J Echocardiogr. 2002;3:159–161
  4. Burke A, Virmani R. Benign Tumours of Fatty Tissue (Tumors of the Heart and Great Vessels). In: (ed 3). Bethseda, MD: Armed Forces Institute of Pathology; 1996;p. 91–98
  5. Shirani J, Roberts WC. Clinical, electrocardiographic and morphologic features of massive fatty deposits (“lipomatous hypertrophy”) in the atrial septum. J Am Coll Cardiol. 1993;22:226–238
  6. Devine WA, Anderson RH. Lipomatous hypertrophy (“massive fatty deposits”) of the interatrial septum. Am J Forensic Med Pathol. 1997;18:107–108
  7. Burke AP, Litovsky S, Virmani R. Lipomatous hypertrophy of the atrial septum presenting as a right atrial mass. Am J Surg Pathol. 1996;20:678–685
  8. O’Connor S, Recavarren R, Nichols LC, et al. Lipomatous hypertrophy of the interatrial septum: an overview. Arch Pathol Lab Med. 2006;130:397–399
  9. Zeebregts CJ, Hensens AG, Timmermans J, et al. Lipomatous hypertrophy of the interatrial septum: indication for surgery?. Eur J Cardiothorac Surg. 1997;11:785–787
  10. Heyer CM, Kagel T, Lemburg SP, et al. Lipomatous hypertrophy of the interatrial septum: a prospective study of incidence, imaging findings, and clinical symptoms. Chest. 2003;124:2068–2073
  11. Reyes CV, Jablokow VR. Lipomatous hypertrophy of the cardiac interatrial septum (A report of 38 cases and review of the literature). Am J Clin Pathol. 1979;72:785–788
  12. Pochis WT, Saeian K, Sagar KB. Usefulness of transesophageal echocardiography in diagnosing lipomatous hypertrophy of the atrial septum with comparison to transthoracic echocardiography. Am J Cardiol. 1992;70:396–398
  13. Nadra I, Dawson D, Schmitz SA, et al. Lipomatous hypertrophy of the interatrial septum: a commonly misdiagnosed mass often leading to unnecessary cardiac surgery. Heart. 2004;90:e66
  14. Stone GW, O’Kell RT, Good TH, et al. Lipomatous hypertrophy of the interatrial septum: diagnosis by percutaneous transvenous biopsy. Am Heart J. 1990;119:406–408
  15. Gay JD, Guileyardo JM, Townsend-Parchman JK, et al. Clinical and morphologic features of lipomatous hypertrophy (“massive fatty deposits”) of the interatrial septum. Am J Forensic Med Pathol. 1996;17:43–48
  16. Alcocer JJ, Katz WE, Hattler BG. Surgical treatment of lipomatous hypertrophy of the interatrial septum. Ann Thorac Surg. 1998;65:1784–1786
  17. Beau P, Michel P, Coisne D, et al. Lipomatous hypertrophy of the cardiac interatrial septum: an unusual complication in long-term home parenteral nutrition in adult patients. JPEN J Parenter Enteral Nutr. 1991;15:659–662
  18. Haenen N, Morshuis W, Heijmen R, et al. Lipomatous hypertrophy of the interatrial septum. Heart. 2002;88:111
  19. Christiansen S, Stypmann J, Baba HA, et al. Surgical management of extensive lipomatous hypertrophy of the right atrium. Cardiovasc Surg. 2000;8:88–90
  20. Noiseux N, Ferraro P, Cousineau G, et al. Combined surgery for lipomatous hypertrophy of the interatrial septum and pulmonary carcinoma. J Thorac Cardiovasc Surg. 2002;123:564–566
  21. Tatli S, O’Gara PT, Lambert J, et al. MRI of atypical lipomatous hypertrophy of the interatrial septum. AJR Am J Roentgenol. 2004;182:598–600
  22. Kato S, Kawata T, Kuwata H, et al. Cardiac liposarcoma at the right ventricular outflow tract (RVOT) following lipomatous hypertrophy of the interatrial septum (LHIS); report of a case. Kyobu Geka. 2004;57:143–146
  23. Uemura S, Watanabe M, Iwama H, et al. Extensive primary cardiac liposarcoma with multiple functional complications. Heart. 2004;90:e48
  24. Breuer M, Wippermann J, Franke U, et al. Lipomatous hypertrophy of the interatrial septum and upper right atrial inflow obstruction. Eur J Cardiothorac Surg. 2002;22:1023–1025
  25. Moinuddeen K, Marica S, Clausi RL, et al. Lipomatous interatrial septal hypertrophy: an unusual cause of intracardiac mass. Eur J Cardiothorac Surg. 2002;22:468–469
  26. Paraf F, Bruneval P, Balaton A, et al. Primary liposarcoma of the heart. Am J Cardiovasc Pathol. 1990;3:175–180
  27. Burke A, Virmani R. Classification and Incidence of Cardiac tumors (Tumors of the Heart and Great Vessels). In: (ed 3). Bethseda, MD: Armed Forces Institute of Pathology; 1996;p. 1–12
  28. Mullen JC, Schipper SA, Sett SS, et al. Right atrial lipoma. Ann Thoracic Surg. 1995;59:1239–1241
  29. Eng J, Ruiz K, Kay PH. Giant epicardial lipoma. Int J Cardiol. 1992;37:115–117
  30. Cooper MJ, deLorimier AA, Higgins CB, et al. Atrial flutter-fibrillation resulting from left atrial compression by an intrapericardial lipoma. Am Heart J. 1994;127:950–951
  31. Li MD, Ho P, Becker MD, et al. Multiple cardiac lipomas and sudden death: a case report and literature review. Cardiovasc Pathol. 1998;7:51–55
  32. Smith MA. Multiple synchronous atrial lipomas. Cardiovasc Pathol. 2007;16:187–188
  33. Sarjeant JM, Butany J, Cusimano RJ. Cancer of the heart: epidemiology and management of primary tumors and metastases. Am J Cardiovasc Drugs. 2003;3:407–421
  34. Val-Bernal JF, Villoria F, Fernandez FA. Polypoid (pedunculated) subepicardial lipoma: a cardiac lesion resembling the epiploic appendage. Cardiovasc Pathol. 2000;9:55–57
  35. Selak I, Plamenac P. Heart hemangiolipoma. Zentralbl Allg Pathol. 1970;113:77–79
  36. Kiaer HW. Myocardial angiolipoma. Acta Pathol Microbiol Immunol Scand [A]. 1984;92:291–292
  37. Heifetz SA, Parikh SR, Brown JW. Hibernoma of the pericardium presenting as pericardial effusion in a child. Pediatr Pathol. 1990;10:575–580
  38. Kindblom LG, Svensson U. Multiple hibernomas of the heart (A case report). Acta Pathol Microbiol Scand [A]. 1977;85A:122–126
  39. Strecker T, Reimann A, Voigt JU, et al. A very rare cardiac hibernoma in the right atrium: a case report. Heart Surg Forum. 2006;9:E623–E625
  40. Dishop MK, O’Connor WN, Abraham S, et al. Primary cardiac lipoblastoma. Pediatr Dev Pathol. 2001;4:276–280
  41. Ben-Izhak O, Elmalach I, Kerner H, et al. Pericardial myolipoma: a tumour presenting as a mediastinal mass and containing oestrogen receptors. Histopathology. 1996;29:184–186
  42. Grande AM, Minzioni G, Pederzolli C, et al. Cardiac lipomas (Description of 3 cases). J Cardiovasc Surg. 1998;39:813–815(Torino)
  43. Tuna IC, Julsrud PR, Click RL, et al. Tissue characterization of an unusual right atrial mass by magnetic resonance imaging. Mayo Clin Proc. 1991;66:498–501
  44. Verkkala K, Kupari M, Maamies T, et al. Primary cardiac tumours: operative treatment of 20 patients. Thorac Cardiovasc Surg. 1989;37:361–364
  45. Vaughan CJ, Weremowicz S, Goldstein MM, et al. A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis. Genes Chromosomes Cancer. 2000;28:133–137
  46. Shirani J, Roberts WC. Epicardial lipoma. Am Heart J. 1993;126:1030
  47. Crotty TB, Edwards WD, Oh JK, et al. Lipomatous hamartoma of the tricuspid valve: echocardiographic-pathologic correlations. Clin Cardiol. 1991;14:262–266
  48. Benvenuti LA, Mansur AJ, Lopes DO, et al. Primary lipomatous tumors of the cardiac valves. South Med J. 1996;89:1018–1020
  49. Wada T, Miyamoto S, Anai H, et al. Aortic valve lipomatous hamartoma in a young woman. Jpn J Thorac Cardiovasc Surg. 2005;53:577–579
  50. Caralps JM, Marti V, Ferres P, et al. Mitral valve repair after excision of a fibrolipoma. Ann Thoracic Surg. 1998;66:1808–1809
  51. Barberger-Gateau P, Paquet M, Desaulniers D, et al. Fibrolipoma of the mitral valve in a child (Clinical and echocardiographic features). Circulation. 1998;58:955–958
  52. Harth M, Ruemmele P, Knuechel-Clarke R, et al. Sclerosed lipoma of the mitral valve. J Heart Valve Dis. 2003;12:722–725
  53. Behnam R, Williams G, Gerlis L, et al. Lipoma of the mitral valve and papillary muscle. Am J Cardiol. 1983;51:1459–1460
  54. Sugiyama K, Naito T, Habu H, et al. A case of cardiac lipoma of the anterior tricuspid leaflet. J Cardiol Suppl. 1992;28:67–75
  55. Anderson DR, Gray MR. Mitral incompetence associated with lipoma infiltrating the mitral valve. Heart. 1988;60:169–171
  56. Vadmal MS, Hajdu SI. Lipoma of the mitral valve in a child. Ann Clin Lab Sci. 1998;28:242–245
  57. Dollar AL, Wallace RB, Kent KM, et al. Mitral valve replacement for mitral lipoma associated with severe obesity. Am J Cardiol. 1989;64:1405–1407
  58. Pederzolli C, Terrini A, Ricci A, et al. Pulmonary valve lipoma presenting as syncope. Ann Thorac Surg. 2002;73:1305–1306
  59. Surdacki A, Kapelak B, Brzozowska-Czarnek A, et al. Lipoma of the aortic valve in a patient with acute myocardial infarction. Int J Cardiol. 2007;115:e36–e38
  60. Matsushita T, Huynh AT, Singh T, et al. Aortic valve lipoma. Ann Thorac Surg. 2007;83:2220–2222
  61. Black MD, Masters RG, Walley VM, et al. Hemoptysis: two unusual causes. Can J Cardiol. 1990;6:27–30
  62. Burke A, Virmani R. Primary cardiac sarcomas. In: Tumors of the Heart and Great Vessels. (ed 3). Bethseda, MD: Armed Forces Institute of Pathology; 1996;p. 127–170
  63. Edo-Dias JA, Queiroz M, Vouga L, et al. Liposarcoma of the heart (A case report). Am J Cardiovasc Pathol. 1990;3:259–263
  64. Cafferty LL, Epstein JI. Primary liposarcoma of the right atrium. Hum Pathol. 1987;18:408–410
  65. Dreyer L, Marik PE, Potgieter AS. Myxoid liposarcoma of the right atrium (A case report). S Afr Med J. 1986;69:572–574
  66. Baubion N, Bloch E, Donne C, et al. Lipomyxosarcoma of the pulmonary veins extending into the left atrium (Repetitive surgical treatment). Presse Med. 1985;14:267–269
  67. Murtra M, Mestres CA, Igual A, et al. Primary liposarcoma of the right ventricle and pulmonary artery: surgical excision and replacement of the pulmonic valve by a Bjork-Shiley tilting disc valve. Thorac Cardiovasc Surg. 1983;31:172–174
  68. Cornaert P, Jacquemart T, Graux P, et al. Primary liposarcoma of the left atrium surgically treated. Arch Mal Coeur Vaiss. 1987;80:1669–1672
  69. Nzayinambaho K, Noel H, Brohet C, et al. Primary cardiac liposarcoma simulating a left atrial myxoma. Thorac Cardiovasc Surg. 1985;33:193–195
  70. Pinelli G, Trihn A, Carteaux JP, et al. Primary liposarcoma of the left ventricle (Apropos of a case and review of the literature). Arch Mal Coeur Vaiss. 1996;89:257–260
  71. Stamm C, Felderhoff T, Herse B, et al. Giant primary cardiac liposarcoma vascularized via the circumflex coronary artery. Eur J Cardiothorac Surg. 1999;16:367–370
  72. Can C, Arpaci F, Celasun B, et al. Primary pericardial liposarcoma presenting with cardiac tamponade and multiple organ metastases. Chest. 1993;103:328
  73. Tronconi L, Bramucci E, Sgalambro A, et al. Primary liposarcoma of the pericardium (Case report). Minerva Cardioangiol. 1976;24:241–247
  74. Lacey CJ, Petch MC. Primary liposarcoma of the pericardium. Thorax. 1979;34:120–122
  75. Rafajlovski S, Tatic V, Stepic V. Primary liposarcoma of the pericardium. Vojnosanit Pregl. 2001;58:205–207
  76. Lionarons RJ, van B, Hitchcock JF. Constrictive pericarditis caused by primary liposarcoma. Thorax. 1990;45:566–567
  77. Galazka K, Ciezarek M, Soja J, et al. Synchronous primary heart liposarcoma and papillary renal carcinoma: a case report. Pol J Pathol. 2003;54:153–159
  78. Kendall SW, Williams EA, Hunt JB, et al. Recurrent primary liposarcoma of the pericardium: management by repeated resections. Ann Thorac Surg. 1993;56:560–562
  79. Llombart-Cussac A, Pivot X, Contesso G, et al. Adjuvant chemotherapy for primary cardiac sarcomas: the IGR experience. Br J Cancer. 1998;78:1624–1628
  80. Burke A, Virmani R. Heterotopias and tumors originating from ectopic tissues. In: Tumors of the Heart and Great Vessels. (ed 3). Bethseda, MD: Armed Forces Institute of Pathology; 1996;p. 111–125
  81. Cina SJ, Smialek JE, Burke AP, et al. Primary cardiac tumors causing sudden death: a review of the literature. Am J Forensic Med Pathol. 1996;17:271–281
  82. Arai T, Kurashima C, Wada S, et al. Histological evidence for cell proliferation activity in cystic tumor (endodermal heterotopia) of the atrioventricular node. Pathol Int. 1998;48:917–923
  83. Saito S, Kobayashi J, Tagusari O, et al. Successful excision of a cystic tumor of the atrioventricular nodal region. Circ J. 2005;69:1293–1294
  84. Vinter S, Isaksen C, Vesterby A. Sudden cardiac death in a young woman: tumor of the atrioventricular (AV) node or citalopram intoxication?. Am J Forensic Med Pathol. 2005;26:349–351
  85. Armstrong H, Monckeberg JG. Herzblock bedingt durch primaren Herz tumor, bei einem 5-jahrigen kind. Dtsch Arch Klin Med. 1911;102:144–166
  86. Linder J, Shelburne JD, Sorge JP, et al. Congenital endodermal heterotopia of the atrioventricular node: evidence for the endodermal origin of so-called mesotheliomas of the atrioventricular node. Hum Pathol. 1984;15:1093–1098
  87. Sopher IM, Spitz WE. Endodermal inclusions of the heart (So-called mesotheliomas of the atrioventricular node). Arch Pathol. 1971;92:180–186
  88. Monma N, Satodate R, Tashiro A, et al. Origin of so-called mesothelioma of the atrioventricular node (An immunohistochemical study). Arch Pathol Lab Med. 1991;115:1026–1029
  89. Duray PH, Mark EJ, Barwick KW, et al. Congenital polycystic tumor of the atrioventricular node (Autopsy study with immunohistochemical findings suggesting endodermal derivation). Arch Pathol Lab Med. 1985;109:30–34
  90. Suarez-Mier MP, Sanchez-de-Leon S, Cohle SD. An unusual site for the AV node tumor: report of two cases. Cardiovasc Pathol. 1999;8:325–328
  91. Wong J, Ball RY. Endodermal heterotopia of the atrioventricular node associated with transposition of the great arteries. Cardiovasc Pathol. 2003;12:159–162
  92. Burke AP, Anderson PG, Virmani R, et al. Tumor of the atrioventricular nodal region (A clinical and immunohistochemical study). Arch Pathol Lab Med. 1990;114:1057–1062
  93. Grigg LE, Downey W, Tatoulis J, et al. Benign congenital intracardiac thyroid and polycystic tumor causing right ventricular outflow tract obstruction and conduction disturbance. J Am Coll Cardiol. 1987;9:225–227
  94. Cameselle-Teijeiro J, Abdulkader I, Soares P, et al. Cystic tumor of the atrioventricular node of the heart appears to be the heart equivalent of the solid cell nests (ultimobranchial rests) of the thyroid. Am J Clin Pathol. 2005;123:369–375
  95. Kaminsky NI, Killip T, Alonso DR, et al. Heart block and mesothelioma of the atrioventricular node. Am J Cardiol. 1967;20:248–254

PII: S0740-2570(07)00098-6

doi: 10.1053/j.semdp.2007.10.002

Seminars in Diagnostic Pathology
Volume 25, Issue 1 , Pages 29-38 , February 2008

Article Tools

* Image Usage & Resolution