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Seminars in Diagnostic Pathology
Volume 23, Issue 2
, Pages 84-90
, May 2006
GIST under imatinib therapy
References
- Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med. 2001;1052:1052–1056
- Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours (A phase I study). Lancet. 2001;358:1421–1423
- Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002;347:472–480
- Phase III dose-randomized study of imatinib mesylate (STI571) for GIST: Intergroup S0033 early results. Proc Am Soc Clin Oncol. 2003;22:814
- Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumors entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer. 2004;40:689–695
- Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. 2004;364:1127–1134
- KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer. 2006;42:1093–1103
- Consensus meeting for the managament of gastrointestinal stromal tumors (Report of the GIST consensus conference of 20-21 March 2004, under the auspices of ESMO). Ann Oncol. 2005;16:566–578
- Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol. 2003;21:4342–4349
- . An update on molecular genetics of gastrointestinal stromal tumours. J Clin Pathol. 2006;59:557–563
- Long-term follow-up of a phase II randomized trial in advanced gastrointestinal stromal tumor (GIST) patients treated with imatinib mesylate. J Clin Oncol. 2006;24:9528
- Resection of residual disease in patients with metastatic gastrointestinal stromal tumors responding to treatment with imatinib. Int J Cancer. 2005;117:316–325
- Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res. 2005;11:4182–4190
- Is there a role for surgery in patients with “unresectable” cKit+ gastrointestinal stromal tumors treated with imatinib mesylate?. Am J Surg. 2003;186:665–669
- CASE 3 (Pathologic complete remission of metastatic gastrointestinal stromal tumor after imatinib mesylate). J Clin Oncol. 2005;23:1580–1582
- Pathological complete response in advanced gastrointestinal stromal tumor after imatinib therapy. Intern Med. 2005;44:1163–1168
- Complete remission of a metastatic gastrointestinal stromal tumour with the tyrosine kinase inhibitor imatinib (STI571): effect of low dosage in an advanced tumour with exon 11 mutation. Eur J Gastroenterol Hepatol. 2003;15:323–327
- Complete remission with imatinib in metastatic gastrointestinal stromal tumors. J Clin Oncol. 2005;23:6800–6801
- PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol. 2005;23:1–8
- Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene. 2004;23:3999–4006
- Apoptotic and anti-vascular activity of imatinib in GIST patients. J Clin Oncol. 2005;23:9001
- . PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev. 2004;15:275–286
- Pericytes and endothelial precursor cells: cellular interactions and contributions to malignanacy. Cancer Res. 2005;65:9741–9750
- PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol. 2005;7:870–879
- The activity of sunitinib (SU11248) against gastrointestinal stromal tumor (GIST) appears to be distinct from its anti-angiogenic effects. Clin Cancer Res. 2006;in press
- Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants. Gastroenterology. 2005;128:270–279
- Acquired resistance to imatinib in gastrointestinal stromal tumours caused by multiple KIT mutations. Lancet Oncol. 2005;6:249–251
- Mechanisms of resistance to imatinib mesylate (IM) in advanced gastrointestinal stromal tumors (GIST). Proc Am Soc Clin Oncol. 2003;22:815
- Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. Clin Cancer Res. 2006;12:1743–1749
- A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res. 2004;64:5913–5919
- Resistance to imatinib, low-grade FDG-avidity on PET, and acquired KIT exon 17 mutation in gastrointestinal stromal tumour. Lancet Oncol. 2005;6:724–727
- A new mutation in the KIT ATP pocket causes acquiered resistance to imatinib in a gastrointestinal stromal tumor patient. Gastroenterology. 2004;127:294–299
- Tamborini E, Pricl S, Negri T, et al: Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients. Oncogene (online June 2006)
- Late resistance to imatinib therapy in a metastatic gastrointestinal stromal tumour is associated with a second KIT mutation. Br J Cancer. 2004;90:2059–2061
- Sunitinib (SU) response in imatinib-resistant (IM-R) GIST correlates with KIT and PDGFRA mutation status. J Clin Oncol. 2006;24:9502
- Changing phenotype of gastrointestinal stromal tumors under imatinib mesylate treatment: a potential diagnostic pitfall. Histopathology. 2005;47:41–47
PII: S0740-2570(06)00141-9
doi: 10.1053/j.semdp.2006.08.005
© 2006 Elsevier Inc. All rights reserved.
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Seminars in Diagnostic Pathology
Volume 23, Issue 2
, Pages 84-90
, May 2006
