Seminars in Diagnostic Pathology
Volume 23, Issue 1 , Pages 15-19 , February 2006

The role of immunohistochemistry in distinguishing squamous cell carcinoma from mesothelioma and adenocarcinoma in pleural effusion

  • Qing Li, MD, PhD

      Affiliations

    • Department of Pathology, The University of Michigan Hospitals, Ann Arbor, Michigan
    • ,
  • Neil Bavikatty, MD

      Affiliations

    • Department of Pathology, Munson Medical Center, Traver City, Michigan.
    • ,
  • Claire W. Michael, MD

      Affiliations

    • Department of Pathology, The University of Michigan Hospitals, Ann Arbor, Michigan
    • Corresponding Author InformationAddress reprint requests and correspondence: Claire W. Michael, MD, Department of Pathology, 2G322, University of Michigan Hospitals, 1500 East Medical Center Drive, Ann Arbor, MI 48109.

References 

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  3. Ordonez NG . The immunohistochemical diagnosis of epithelial mesothelioma . Hum Pathol . 1999;30:313–323
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  15. Athanassiadou P , Athanassiades P , Lazaris D , et al.   Immunocytochemical differentiation of reactive mesothelial cells and adenocarcinoma cells in serous effusions with the use of carcinoembryonic antigen and fibronectin . Acta Cytol . 1994;38:718–722
  16. Wang NS , Huang SN , Gold P . Absence of carcinoembryonic antigen-like material in mesothelioma . Cancer . 1979;44:937–943
  17. Sheibani K , Battifora H , Burke JS . Antigenic phenotype of malignant mesotheliomas and pulmonary adenocarcinomas: an immunohistologic analysis demonstrating the value of Leu M1 antigen . Am J Pathol . 1986;123:212–219
  18. Bailey ME , Brown RW , Mody DR , et al.   Ber-EP4 for differentiating adenocarcinoma from reactive and neoplastic mesothelial cells in serous effusions (Comparison with carcinoembryonic antigen, B72.3 and Leu-M1) . Acta Cytol . 1996;40:1212–1216
  19. Riera JR , Astengo-Osuna C , Longmate JA , et al.   The immunohistochemical diagnostic panel for epithelial mesothelioma: a reevaluation after heat-induced epitope retrieval . Am J Surg Pathol . 1997;21:1409–1419
  20. Maguire B , Whitaker D , Carrello S , et al.   Monoclonal antibody Ber-EP4: its use in the differential diagnosis of malignant mesothelioma and carcinoma in cell blocks of malignant effusions and FNA specimens . Diagn Cytopathol . 1994;10:130–134
  21. Moch H , Oberholzer M , Dalquen P , et al.   Diagnostic tools for differentiating between pleural mesothelioma and lung adenocarcinoma in paraffin embedded tissue (Part I: Immunohistochemical findings) . Virchows Arch A Pathol Anat Histopathol . 1993;423:19–27

PII: S0740-2570(06)00090-6

doi: 10.1053/j.semdp.2006.06.007

Seminars in Diagnostic Pathology
Volume 23, Issue 1 , Pages 15-19 , February 2006

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