Seminars in Diagnostic Pathology
Volume 23, Issue 1 , Pages 4-14 , February 2006

Distinguishing benign mesothelial hyperplasia from neoplasia: a practical approach

  • Richard L. Kradin, MD

      Affiliations

    • Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts
    • Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
    • Corresponding Author InformationAddress reprint requests and correspondence: Richard L. Kradin, MD, Department of Pathology, Massachusetts General Hospital, Warren-253, Boston, MA 02114.
    • ,
  • Eugene J. Mark, MD

      Affiliations

    • Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

References 

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  4. Andrews PM , Porter KR . The ultrastructural morphology and possible functional significance of mesothelial microvilli . Anat Rec . 1973;177:409–426
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  8. Owens M , Grisham M . Nitric oxide synthesis by rat pleural mesothelial cells-induction by cytokines and lipopolysaccharide . Am J Physiol . 1993;265:110–116
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  11. Churg A , Cagle PT , Roggli VL . Tumors of the Serosal Membranes (AFIP Atlas of Tumor Pathology) . ed 3. Washington DC: American Registry of Pathology; 2006;
  12. McCaughey WT , Kannerstein M , Churg J . (2nd series ed).. Tumors and Pseudotumors of the Serous Membranes . Vol. Fascicle 20. Washington DC: Armed Forces Institute of Pathology; 1985; Atlas of Tumor Pathology
  13. Attanoos RL , Suvarna SK , Rhead E , et al.   Malignant vascular tumours of the pleura in “asbestos” workers and endothelial differentiation in malignant mesothelioma . Thorax . 2000;55:860–863
  14. Henderson DW , Shilkin KB , Whitaker D . Reactive mesothelial hyperplasia vs mesothelioma, including mesothelioma in situ: a brief review . Am J Clin Pathol . 1998;110:397–404
  15. Whitaker D , Henderson DW , Shilkin KB . The concept of mesothelioma in situ: implications for diagnosis and histogenesis . Semin Diagn Pathol . 1992;9:151–161
  16. Mangano WE , Cagle PT , Chung A , et al.   The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining . Am J Clin Pathol . 1998;110:191–199
  17. Attanoos RL , Griffin A , Gibbs AR . The use of immunohistochemistry in distinguishing reactive form neoplastic mesothelium (A novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, P-glycoprotein and Bcl-2) . Histopathology . 2003;43:231–238
  18. Cury PM , Butcher PN , Corrin B , et al.   The use of histological and imminohistochemical markers to distinguish pleural malignant mesothelioma ans in situ mesothelioma form reactive mesothelial hyperplasia and reactive pleural fibrosis . J Pathol . 1999;189:251–257
  19. Creaney J , McLaren BM , Stevenson S , et al.   p53 autoantibodies in patients with malignant mesothelioma: stability through disease progression . Br J Cancer . 2001;84:52–56
  20. Cagle PT , Brown RW , Lebovitz RM . p53 immunostaining in the differentiation of reactive process from malignancy in pleural biopsy specimens . Hum Pathol . 1994;25:443–448

PII: S0740-2570(06)00088-8

doi: 10.1053/j.semdp.2006.06.005

Seminars in Diagnostic Pathology
Volume 23, Issue 1 , Pages 4-14 , February 2006

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