Seminars in Diagnostic Pathology
Volume 20, Issue 2 , Pages 84-93 , May 2003

Splenic histology and histopathology: an update

  • Madeleine D Kraus, MD

      Affiliations

    • Division of Immunopathology, Department of Pathology, Weill Medical College of Cornell Medical Center, New York, NY, USA
    • Corresponding Author InformationAddress reprint requests to Madeleine D. Kraus, MD, Division of Immunopathology — Starr 709, Weill Medical College of Cornell Medical Center, 525 East 68th St, New York, NY 10021, USA

References 

  1. Timens W, Rozenboom-Uiterwijk T, Poppema S. Fetal and neonatal development of the human spleen (An immunohistochemical study). Immunology. 1987;60:603–609
  2. Roberts CW, Shutter JR, Korsmeyer SJ. Hox11 controls the genesis of the spleen. Nature. 1994;368:747–749
  3. Dear TN, Colledge WH, Carlton MB, et al.  The Hox11 gene is essential for cell survival during spleen development. Development. 1995;121:2909–2915
  4. Roberts CW, Sonder AM, Lumsden A, et al.  Developmental expression of HOX11 and specification of splenic cell fate. Am J Pathol. 1995;146:1089–1101
  5. Lu J, Chang P, Richardson JA, et al.  The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Proc Nat Acad Sci. 2000;97:9525–9530
  6. Patterson M. A mean spleen gene. Nat Rev Genet. 2000;1:8; [Comment]
  7. Van Krieken JHJM, Feller AC, te Velde J. The distribution of non-Hodgkin’s lymphoma in the lymphoid compartments of the human spleen. Am J Surg Pathol. 1989;13:757–765
  8. Van Krieken JHJM, te Velde . Normal histology of the spleen. In:  Sternberg S editors. Histology for Pathologists. New York, NY: Raven Press; 1991;p. 253–260
  9. Steininger B, Barth P, Herbst B, et al.  The species-specific structure of microanatomical compartments in the human spleen. Immunology. 1997;92:307–316
  10. Edelman M, Evans L, Zee S, et al.  Splenic micro-anatomical localization of small lymphocytic lymphoma/chronic lymphocytic leukemia using a novel combined silver nitrate and immunoperoxidase technique. Am J Surg Pathol. 1997;21:445–452
  11. Van Krieken JHJM, te Velde J. Immunohistology of the human spleen (Inventory of the localization of lymphocyte subpopulations). Histopathology. 1986;10:285–294
  12. Arber DA, Strickler JG, Chen YY, et al.  Splenic vascular tumors (An histologic, immunophenotypic, and virologic study). Am J Surg Pathol. 1997;21:827–835
  13. Rosso R, Gianelli U, Chan JKC. Further evidence supporting the sinus lining cell nature of splenic littoral cell angiosarcoma. [letter] Am J Surg Pathol. 1996;20:1531
  14. Zukerberg LR, Kaynor BL, Silverman ML, et al.  Splenic hamartoma and capillary hemangioma are distinct entities (Immunohistochemical evaluation of CD8 expression by endothelial cells). Hum Pathol. 1991;22:1258–1261
  15. Pinkus GS, Warhol MJ, O’Connor EM, et al.  Immunohistochemical localization of smooth muscle myosin in human spleen, lymph nodes and other lymphoid tissue (Unique staining pattern in white pulp and sinuses, lymphoid follicles and certain vasculature, with ultrastructural correlations). Am J Pathol. 1986;1223:440–453
  16. Toccanier-Pelte MF, Skalli O, Kamanci Y, et al.  Characterization of splenic stromal cells with myoid features in normal and pathologic conditions. Am J Pathol. 1987;129:109–118
  17. Wilkins BS, Jones DB, Treasure JM, Delsol G. Alpha smooth muscle actin expression and white pulp compartmentalization in normal and reactive spleen. J Anatomy. 1995;187:206
  18. Steiniger B, Barth P, Hellinger A. The perifollicular and marginal zones of the splenic white pulp (Do fibroblasts guide lymphocyte immigration?). Am J Pathol. 2001;159:501–512
  19. Bourdessoule D, Gaulard P, Mason DY. Preferential localization of human lymphocytes bearing γ/δ T cell receptors to the red pulp of the spleen. J Clin Pathol. 1990;43:461–464
  20. Satoh T, Takeda R, Oikawa H, et al.  Immunohistochemical and structural characteristic of the reticular framework of the white pulp and marginal zone in the human spleen. Anatom Rec. 1997;249:486–494
  21. Spencer J, Perry ME, Dunn-Walters DK. Human marginal-zone B cells. Immunol Today. 1998;19:421–426
  22. Kraus MD, Fleming MD, Vonderheide RH. The diagnostic splenectomy (10 years’ experience at two tertiary care institutions). Cancer. 2001;91:2001–2009
  23. Kraus MD, Bartlett NL, Fleming MD, et al.  Splenic pathology in myelo-dysplasia (A report of 13 cases with clinical correlation). Am J Surg Pathol. 1998;22:1255–1266
  24. Cronin CC, Brady MP, Murphy C, et al.  Splenectomy in patients with undiagnosed splenomegaly. Postgrad Med J. 1994;70:288–329
  25. Delsol G, Diebold J, Isaacson PG, et al.  Pathology of the spleen (Report on the Workshop of the VIIIth meeting of the European Association for Hematopathology). Histopathology. 1988;32:172–179
  26. Letoquart J-P, La Gamma A, Kunin N, et al.  Splenectomy for splenomegaly exceeding 1000 gm (Analysis of 47 patients). Br J Surg. 1993;80:334–335
  27. Pawade J, Wilkins BS, Wright DH. Low-grade B-cell lymphomas of the splenic marginal zone (A clinicopathological and immunohistochemical study of 14 cases). Histopathology. 1995;27:129–137
  28. Pittaluga S, Verhoef G, Criel A, et al.  “Small” B-cell non-Hodgkin’s lymphomas with splenomegaly at presentation are either mantle cell lymphoma or marginal zone cell lymphoma. Am J Surg Pathol. 1996;20:211–223
  29. Palutke M, Eisenberg L, Narang S, et al.  B lymphocytic lymphoma (large cell) of possible splenic marginal zone origin presenting with prominent splenomegaly and unusual red pulp distribution. Cancer. 1988;62:593–600
  30. Cummings OW, Mazur MT. Breast cancer diffusely metastatic to the spleen (Two cases presenting as idiopathic thrombocytopenic purpura). Am J Clin Pathol. 1992;97:484–489
  31. Burke JS. Surgical pathology of the spleen: an approach to differential diagnosis of splenic lymphomas and leukemias. Part II:Diseases of Red Pulp. Am J Surg Pathol. 1981;5:681–694
  32. Burke JS. Splenic lymphoid hyperplasia versus lymphoma/leukemia (A diagnostic guide). Am J Clin Pathol. 1993;99: 486–449
  33. Farhi DC, Ashfaq R. Splenic pathology after traumatic injury. Am J Clin Pathol. 1996;105:474–478
  34. Drachenberg CB, Papadimitriou JC. Splenic pathology in different forms of traumatic injury. Am J Clin Pathol. 1996;106:695; [letter]
  35. Ost A, Nilsson-Ardnor S, Henter JI. Autopsy findings in 27 children with hemophagocytic lymphohistiocytosis. Histopathology. 1998;32:310–316
  36. Gaffey MJ, Frierson HF, Medeiros LJ, et al.  The relationship of Epstein-Barr virus to infection-related (sporadic) and familial hemophagocytic syndrome and secondary hemophagocytosis (An in situ hybridization study). Hum Pathol. 1993;24:657–667
  37. Marti M, Feliu E, Campo E, et al.  Comparative study of spleen pathology in drug abusers with thrombocytopenia related to human immunodeficiency virus infection and in patients with idiopathic thrombocytopenic purpura. Am J Clin Pathol. 1993;100:633–642
  38. Jaffe ES, Costa J, Fauci AS, et al.  Malignant lymphoma and erythrophagocytosis simulating malignant histiocytosis. Am J Med. 1983;75:741–749
  39. Mori N, Yamashita Y, Tsuzuki T, et al.  Lymphomatous features of aggressive NK cell leukaemia/lymphoma with massive necrosis, haemophagocytosis and EB virus infection. Histopathology. 2000;37:363–371
  40. Parizshakaya M, Reyes J, Jaffe R. Hemophagocytic syndrome presenting as acute hepatic failure in two infants (Clinical overlap with neonatal hemochromatosis). Pediatr Dev Pathol. 1999;2:360–366
  41. Wilkins BS, Green A, Wild AE, et al.  Extramedullary haemopoiesis in fetal and adult human spleen (A quantitative immunohistological study). Histopathology. 1994;24:241–247
  42. Mackie M, Shephard B. The spleen in myeloproliferative disorders. In:  Cuschieri A,  Forbes C editor. Disorders of the Spleen. Oxford: Blackwell Scientific Press; 1994;p. 121–137
  43. Mesa RA, Li CY, Schroeder G, et al.  Clinical correlates of splenic Histopathology and splenic karyotype in myelofibrosis with myeloid metaplasia. Blood. 2001;97:3665–3667
  44. Kraus MD. personal observation. 2002; October
  45. Beckman EN, Oehrle JS. Fibrous hematopoietic tumors arising in agnogenic myeloid metaplasia. Hum Pathol. 1982;13:804–810
  46. Falkan F, Michal M. Nodular transformation of splenic red pulp due to carcinomatous infiltration (A diagnostic pitfall). Histopathology. 1994;25:175–178
  47. Burke JS. Extranodal hematopoietic/lymphoid disorders. Am J Clin Pathol. 1999;111(Suppl 1):S40–S45
  48. Falk S, Stutte HJ. Manifestations of malignant lymphomas in the spleen (An histologic and immunohistochemical study of 500 cases). Prog Surg Pathol. 1992;12:49–95
  49. Rakozy CK, Mohamed AN, Vo TD, et al.  CD56+/CD4+ lymphomas and leukemias are morphologically, immunophenotypically, cytogenetically, and clinically diverse. Am J Clin Pathol. 2001;116:168–176
  50. Yoe J, Gause BL, Curti BD, et al.  Development of rheumatoid arthritis after treatment of large granular lymphocyte leukemia with deoxycofromaycin. Am J Hematol. 1998;57:253–257
  51. Yoe J, Gause BL, Curti BD, et al.  Development of rheumatoid arthritis after treatment of large granular lymphocyte leukemia with deoxycofromaycin. Am J Hematol. 1998;57:253–257
  52. Lamy T, Loughran TP. Current concepts (Large granular lymphocyte leukemia). Blood Rev. 1999;13:230–240
  53. Agnarsson BA, Loughran TP, Starkenbaum G, et al.  The pathology of large granular lymphocyte leukemia. Hum Pathol. 1989;20:643–651
  54. Nagakawa A, Masafum I, Saga S. Fatal cytotoxic T cell proliferatinin chronic active Epstein Barr virus infection in childhood. Am J Clin Pathol. 2002;117:283–290
  55. Shin SS, Berry GJ, Weiss LM. Infectios monucleosis (Diagnosis by in situ hybridization in two cases with atypical features). Am J Surg Pathol. 1991;15:625–631
  56. Strickler JG, Fedeli F, Horwitz CA, et al.  Infectious mononucleosis in lymphoid tissue. Arch Pathol Lab Med. 1993;117:269–278
  57. Satoh T, Yamada T, Nakano S, et al.  The relationship between primary splenic malignant lymphoma and chronic liver disease associated with hepatitis C virus infection. Cancer. 1997;80:1981–1988
  58. Agnello V, Mecucci C, Casato M. Regression of splenic lymphoma after treatment of hepatitis C virus infection. N Engl J Med. 2002;347:2168–2170
  59. Timesn W, Poppema S. Lymphocyte compartments in human spleen (An immunohistological study). Am J Pathol. 1985;120:443–454
  60. Burke JS. Surgical pathology of the spleen: An approach to differential diagnosis of splenic lymphomas and leukemias. Part I: Diseases of White Pulp. Am J Surg Pathol. 1981;5:551–563
  61. Isaacson PG. Malignant lymphomas with a follicular growth pattern. Histopathology. 1996;28:487–495
  62. Izumi M, Mochizuki M, Kuroda M, et al.  Angiomyoid proliferative lesion (an unusual stroma-rich variant of Castleman’s disease of hyaline-vascular type). Virchows Archiv. 2002;441:400–405
  63. Ordi J, Grau JM, Junque A, et al.  Secondary (AA) amyloidosis associated with Castleman’s disease (Report of 2 cases and a review of the literature). Am J Clin Pathol. 1993;100:394–397
  64. Alkan S, Ross CR, Hanson CA, et al.  Follicular lymphoma with involvement of the splenic marginal zone (A pitfall in the differential diagnosis of splenic marginal zone lymphoma). Hum Pathol. 1996;27:503–506
  65. Schmid U, Cogliatti SB, Diss TC, et al.  Monocytoid/marginal zone B cell differentiation in follicle center cell lymphoma. Histopathology. 1996;29:201–208
  66. Kurtin PJ. Marginal zone B cells, monocytoid B cells, and the follicular microenvironment (Determinants of morphologic features in a subset of low-grade B-cell lymphomas). Am J Clin Pathol. 2000;114:505–508

PII: S0740-2570(03)00024-8

doi: 10.1016/S0740-2570(03)00024-8

Seminars in Diagnostic Pathology
Volume 20, Issue 2 , Pages 84-93 , May 2003